Segall, Lauren and Verwey, Michael and Amir, Shimon (2008) Timed restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized rats. Neuroscience, 157 (1). pp. 52-56. ISSN 0306-4522
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Official URL: http://dx.doi.org/doi:10.1016/j.neuroscience.2008....
Feeding schedules that limit food availability to a set time of day are powerful synchronizers of the rhythms of expression of the circadian clock protein Period 2 (PER2) in the limbic forebrain in rats. Little is known, however, about the mechanisms that mediate the effect of such timed restricted feeding (TRF) schedules on the expression of PER2. Adrenal glucocorticoids have been implicated in the circadian regulation of clock genes expression in peripheral tissues as well as in the control of the rhythms of expression of PER2 in certain limbic forebrain regions, such as the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and central nucleus of the amygdala (CEA) in rats. To study the possible involvement of glucocorticoids in the regulation of PER2 expression by TRF, we assessed the effect of adrenalectomy on TRF-entrained PER2 rhythms in the limbic forebrain in rats. Adrenalectomy selectively abolished the rhythms of PER2 in the BNSTov and CEA in normally fed rats, as previously shown, but had no effect on TRF-entrained PER2 rhythms in the same structures. These findings show that the effect of TRF on PER2 rhythms in the limbic forebrain is independent of adrenal glucocorticoids and demonstrate that the involvement of glucocorticoids in the regulation PER2 rhythms in the limbic forebrain is not only region specific, as previously shown, but also state dependent.
|Divisions:||Concordia University > Faculty of Arts and Science > Psychology|
|Authors:||Segall, Lauren and Verwey, Michael and Amir, Shimon|
|Journal or Publication:||Neuroscience|
|Deposited By:||SHIMON AMIR|
|Deposited On:||26 Apr 2010 16:17|
|Last Modified:||08 Dec 2010 18:32|
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