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The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle

Title:

The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle

Perrin, Jennifer and Segall, Lauren and Harbour, Valerie L. and Woodside, Barbara and Amir, Shimon (2006) The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle. Proceedings of the National Academy of Sciences of the United States of America, 103 (14). pp. 5591-5596. ISSN 0027-8424

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Official URL: http://dx.doi.org/10.1073/pnas.0601310103

Abstract

Daily behavioral and physiological rhythms are linked to circadian oscillations of clock genes in the brain and periphery that are synchronized by the master clock in the suprachiasmatic nucleus. In addition, there are a number of inputs that can influence circadian oscillations in clock gene expression in a tissue-specific manner. Here we identify an influence on the circadian oscillation of the clock protein PER2, endogenous changes in ovarian steroids, within two nuclei of the limbic forebrain: the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala. We show that the daily rhythm of PER2 expression within these nuclei but not in the suprachiasmatic nucleus, dentate gyrus, or basolateral amygdala is blunted in the metestrus and diestrus phases of the estrus cycle. The blunting of the PER2 rhythm at these phases of the cycle is abolished by ovariectomy and restored by phasic estrogen replacement suggesting that fluctuations in estrogen levels or their sequelae are necessary to produce these effects. The finding that fluctuations in ovarian hormones have area-specific effects on clock gene expression in the brain introduces a new level of organizational complexity in the control of circadian rhythms of behavior and physiology.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Perrin, Jennifer and Segall, Lauren and Harbour, Valerie L. and Woodside, Barbara and Amir, Shimon
Journal or Publication:Proceedings of the National Academy of Sciences of the United States of America
Date:April 2006
Funders:
  • CIHR
  • NSERC
  • CURC
ID Code:6614
Deposited By:SHIMON AMIR
Deposited On:04 May 2010 12:17
Last Modified:08 Dec 2010 18:30
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