Breadcrumb

 
 

Food-entrainable circadian oscillators in the brain

Title:

Food-entrainable circadian oscillators in the brain

Verwey, Michael and Amir, Shimon (2009) Food-entrainable circadian oscillators in the brain. European Journal of Neuroscience, 30 (9). pp. 1650-1657. ISSN 0953-816X

This is the latest version of this item.

[img]
Preview
PDF (pre-print) - Submitted Version
772Kb

Official URL: http://dx.doi.org/10.1111/j.1460-9568.2009.06960.x

Abstract

Circadian rhythms in mammalian behaviour and physiology rely on daily oscillations in the expression of canonical clock genes. Circadian rhythms in clock gene expression are observed in the master circadian clock, the suprachiasmatic nucleus but are also observed in many other brain regions that have diverse roles, including influences on motivational and emotional state, learning, hormone release and feeding. Increasingly, important links between circadian rhythms and metabolism are being uncovered. In particular, restricted feeding (RF) schedules which limit food availability to a single meal each day lead to the induction and entrainment of circadian rhythms in food-anticipatory activities in rodents. Food-anticipatory activities include increases in core body temperature, activity and hormone release in the hours leading up to the predictable mealtime. Crucially, RF schedules and the accompanying food-anticipatory activities are also associated with shifts in the daily oscillation of clock gene expression in diverse brain areas involved in feeding, energy balance, learning and memory, and motivation. Moreover, lesions of specific brain nuclei can affect the way rats will respond to RF, but have generally failed to eliminate all food-anticipatory activities. As a consequence, it is likely that a distributed neural system underlies the generation and regulation of food-anticipatory activities under RF. Thus, in the future, we would suggest that a more comprehensive approach should be taken, one that investigates the interactions between multiple circadian oscillators in the brain and body, and starts to report on potential neural systems rather than individual and discrete brain areas.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Verwey, Michael and Amir, Shimon
Journal or Publication:European Journal of Neuroscience
Date:November 2009
Funders:
  • CIHR
  • FRSQ
  • CURC
ID Code:6617
Deposited By:SHIMON AMIR
Deposited On:04 May 2010 12:33
Last Modified:08 Dec 2010 18:29
Related URLs:

Available Versions of this Item

  • Food-entrainable circadian oscillators in the brain. (deposited 04 May 2010 12:33) [Currently Displayed]
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Document Downloads

More statistics for this item...

Concordia University - Footer