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A forty-year journey in plant research: original contributions to flavonoid biochemistry

Title:

A forty-year journey in plant research: original contributions to flavonoid biochemistry

Ibrahim, Ragai K. (2005) A forty-year journey in plant research: original contributions to flavonoid biochemistry. Canadian Journal of Botany, 83 (5). pp. 433-450. ISSN 0008-4026

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Official URL: http://dx.doi.org/10.1139/b05-030

Abstract

This review highlights original contributions by the author to the field of flavonoid biochemistry during his research career of more than four decades. These include elucidation of novel aspects of some of the common enzymatic reactions involved in the later steps of flavonoid biosynthesis, with emphasis on methyltransferases, glucosyltransferases, sulfotransferases, and an oxoglutarate-dependent dioxygenase, as well as cloning, and inferences about phylogenetic relationships, of the genes encoding some of these enzymes. The three-dimensional structure of a flavonol O-methyltransferase was studied through homology-based modeling, using a caffeic acid O-methyltransferase as a template, to explain their strict substrate preferences. In addition, the biological significance of enzymatic prenylation of isoflavones, as well as their role as phytoanticipins and inducers of nodulation genes, are emphasized. Finally, the potential application of knowledge about the genes encoding these enzyme reactions is discussed in terms of improving plant productivity and survival, modification of flavonoid profiles, and the search for new compounds with pharmaceutical and (or) nutraceutical value.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Refereed:Yes
Authors:Ibrahim, Ragai K.
Journal or Publication:Canadian Journal of Botany
Date:May 2005
Keywords:flavonoid enzymology, metabolite localization, gene cloning, 3-D structure, phylogeny
ID Code:6773
Deposited By:DANIELLE DENNIE
Deposited On:13 Jul 2010 11:18
Last Modified:08 Dec 2010 18:08
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