Titorenko, Vladimir I. and Rachubinski, Richard A. (2000) Peroxisomal Membrane Fusion Requires Two Aaa Family Atpases, Pex1p and Pex6p. The Journal of Cell Biology, 150 (4). pp. 881-886. ISSN 0021-9525
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Official URL: http://dx.doi.org/10.1083/jcb.150.4.881
Two AAA family ATPases, NSF and p97, have been implicated in membrane fusion during assembly and inheritance of organelles of the secretory pathway. We have now investigated the roles of AAA ATPases in membrane fusion during assembly of the peroxisome, an organelle outside the classical secretory system. Here, we show that peroxisomal membrane fusion in the yeast Yarrowia lipolytica requires two AAA ATPases, Pex1p and Pex6p. Release of membrane- associated Pex1p and Pex6p drives the asymmetric priming of two fusion partners. The next step, peroxisome docking, requires release of Pex1p from one partner. Subsequent fusion of the peroxisomal membranes is independent of both Pex1p and Pex6p.
|Divisions:||Concordia University > Faculty of Arts and Science > Biology|
|Authors:||Titorenko, Vladimir I. and Rachubinski, Richard A.|
|Journal or Publication:||The Journal of Cell Biology|
|Date:||21 August 2000|
|Deposited By:||DANIELLE DENNIE|
|Deposited On:||11 May 2011 13:06|
|Last Modified:||11 May 2011 13:06|
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