Hickey, Donal A.
Highly similar noncoding genomic DNA sequences: ultraconserved, or merely widespread?
- Published Version
Official URL: http://dx.doi.org/10.1139/G08-011
In this note, I propose an explanation for the seeming contradiction between bioinformatics-based predictions of an essential function for ultraconserved DNA sequences, and the lack of an experimental demonstration of such function.
References:Ahituv N, Zhu Y, Visel A, Holt A, Afzal V, Pennacchio LA, Rubin EM. 2007. Deletion of ultraconserved elements yields viable mice. PLoS Biol. 5: e234.
Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS, Haussler D. 2004. Ultraconserved elements in the human genome. Science (Washington, D.C.) 304: 1321-1325.
Clark JB, Maddison WP, Kidwell MG. 1994. Phylogenetic analysis supports horizontal transfer of P transposable elements. Mol. Biol. Evol. 11: 40-50.
Drake JA, Bird C, Nemesh J, Thomas DJ, Newton-Cheh C, Reymond A, et al.. 2006. Conserved noncoding sequences are selectively constrained and not mutation cold spots. Nat. Genet. 38: 223-227.
Hickey DA. 1982. Selfish DNA: a sexually-transmitted nuclear parasite. Genetics 101: 519-531.
Katzman S, Kern AD, Bejerano G, Fewell G, Fulton L, Wilson RK, et al.. 2007. Human genome ultraconserved elements are ultraselected. Science (Washington, D.C.) 317: 915.
Nishihara H, Smit AF, Okada N. 2006. Functional noncoding sequences derived from SINEs in the mammalian genome. Genome Res. 16: 864-874.
Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, et al.. 2006. In vivo enhancer analysis of human conserved non-coding sequences. Nature (London) 444: 499-502.
Pennisi E. 2007. Evolution: jumping genes hop into the evolutionary limelight. Science (Washington, D.C.) 317: 894-895.
Piskurek O, Okada N. 2007. Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals. Proc. Natl. Acad. Sci. U.S.A. 104: 12046-12051.
Sánchez-Gracia A, Maside X, Charlesworth B. 2005. High rate of horizontal transfer of transposable elements in Drosophila. Trends Genet. 21: 200-203.
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access
Repository Staff Only: item control page