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Catalytic role of copper in nitric oxide transfer from S-nitrosothiols to low-molecular-weight thiols

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Catalytic role of copper in nitric oxide transfer from S-nitrosothiols to low-molecular-weight thiols

Ciortea, Mihai (2004) Catalytic role of copper in nitric oxide transfer from S-nitrosothiols to low-molecular-weight thiols. Masters thesis, Concordia University.

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Abstract

In recent years, much attention has been focused on the chemistry and biology of nitric oxide due to the discovery that it plays a key role in a wide variety of physiological processes. It has been suggested that S-nitrosothiols may be directly involved in many of the biological functions of nitric oxide and that they play a role in nitric oxide storage, transport and delivery. The mechanism of nitric oxide transfer from an S-nitrosothiol to a low-molecular-weight thiol or to a protein-based thiol is still unknown. In this work, evidence for a mechanism in which traces of copper play a role in nitric oxide transfer between thiols is presented. A new synthesis for dansyl homocysteine is described and this fluorescent thiol is used as a direct and sensitive nitric oxide-transfer probe. The results demonstrate that redox turnover of copper is required for efficient nitric oxide transfer between low-molecular-weight thiols.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Thesis (Masters)
Authors:Ciortea, Mihai
Pagination:xiii, 80 leaves : ill. ; 29 cm.
Institution:Concordia University
Degree Name:M. Sc.
Program:Chemistry and Biochemistry
Date:2004
Thesis Supervisor(s):English, Ann M
ID Code:8126
Deposited By: Concordia University Libraries
Deposited On:18 Aug 2011 18:16
Last Modified:18 Aug 2011 19:46
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