Breadcrumb

 
 

Synthesis of aromatic peptide nucleic acids

Title:

Synthesis of aromatic peptide nucleic acids

Boyd, Michael J (1999) Synthesis of aromatic peptide nucleic acids. Masters thesis, Concordia University.

[img]
Preview
PDF
3176Kb

Abstract

The synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic backbone which may improve cell permeability. Such analogues may be useful as antisense/antigene therapeutic agents. A first generation APNA hexamer, composed of monomers of general structure A was synthesized in solution. Thermal denaturation studies failed to indicate if these compounds hybridize to DNA or RNA. The second generation APNA monomers ( B ) were incorporated into PNA hexamers by solid phase peptide synthesis. The resulting PNA/APNA chimeras hybridize to both DNA and RNA by triple helix formation, however these complexes were found to be less stable than the unmodified PNAs

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Thesis (Masters)
Authors:Boyd, Michael J
Pagination:xvi, 126 leaves : ill. ; 29 cm.
Institution:Concordia University
Degree Name:Theses (M.Sc.)
Program:Chemistry and Biochemistry
Date:1999
Thesis Supervisor(s):Tsantrizos, Youla S
ID Code:856
Deposited By:Concordia University Libraries
Deposited On:27 Aug 2009 13:14
Last Modified:08 Dec 2010 10:17
Related URLs:
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Document Downloads

More statistics for this item...

Concordia University - Footer