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The role of dopamine in acute food deprivation-induced reinstatement of heroin seeking

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The role of dopamine in acute food deprivation-induced reinstatement of heroin seeking

Tobin, Stephanie (2007) The role of dopamine in acute food deprivation-induced reinstatement of heroin seeking. Masters thesis, Concordia University.

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Abstract

Dopamine (DA) has been shown to play a significant role in drug reinforcement and the reinstatement of drug seeking due to priming or drug cue presentations. However, DA is suggested to play a limited role in stress-induced reinstatement, as modelled by footshock-induced reinstatement. Here the role of DA in acute food deprivation (FD)-induced reinstatement of heroin seeking, an alternative model of stress-induced reinstatement, is investigated. Rats were trained to self-administer heroin (0.05 mg/kg/infusion) for 10 days (days 1-5: 3 X 3 h sessions; days 6-10: 1 X 3 h session). Heroin-seeking behavior was extinguished by removing the drug. Following extinction, rats were tested for 48 h FD-induced reinstatement while pretreated with specific DA receptor antagonists. An attenuation of drug seeking was seen in rats given the high dose (10.0 og/kg) of the DA D 1 receptor antagonist, SCH 23390; but, not the low dose of this antagonist (5.0 og/kg) or the DA D 2 and D 3 receptor antagonists raclopride (50.0 and 100.0 og/kg) and NGB 2904 (0.1 and 5.0 mg/kg). The lack of effect for raclopride on FD-induced reinstatement was validated by demonstrating a role for this antagonist on cue-induced reinstatement of extinguished heroin seeking. These results suggest that FD-induced reinstatement may be mediated, at least in part, by the activation of the DA D 1 receptor. Moreover, since systemic injection of SCH 23390 has previously been shown to have no effect on footshock-induced reinstatement the current study suggests that DA transmission may play a differential role in footshock and FD-induced reinstatement.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Thesis (Masters)
Authors:Tobin, Stephanie
Pagination:viii, 73 leaves : ill. ; 29 cm.
Institution:Concordia University
Degree Name:M.A.
Program:Psychology
Date:2007
Thesis Supervisor(s):Shalev, Uri
ID Code:975519
Deposited By: Concordia University Library
Deposited On:22 Jan 2013 16:09
Last Modified:18 Jan 2018 17:40
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