Login | Register

Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation

Title:

Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation

Aleksanian, Samuel, Khorsand, Behnoush, Schmidt, Rolf and Oh, Jung Kwon (2012) Rapidly thiol-responsive degradable block copolymer nanocarriers with facile bioconjugation. Polymer Chemistry, 3 (8). p. 2138. ISSN 1759-9954

[img]
Text (application/msword)
OH-PC-PES-b-POEOMA.doc - Accepted Version
Available under License Spectrum Terms of Access.
3MB

Official URL: http://dx.doi.org/10.1039/C2PY20154B

Abstract

Degradation of amphiphilic block copolymer (ABP) micelles in response to external stimuli (stimuli-responsive degradation) is a desired property in the design of controlled delivery vehicles. Here, a versatile methodology that combines facile carbodiimide coupling polycondensation with controlled radical polymerization to synthesize thiol-responsive degradable ABP micelles is described. These smart micelles consist of a hydrophobic degradable polyester block with disulfide linkages labeled repeatedly along the main chain; more importantly, in response to thiols they exhibit rapid and controlled degradation, thereby leading to enhanced release of encapsulated model drugs. Moreover, the proposed method allows for a facile bioconjugation of hydrophilic coronas using cell-targeting biomolecules during polymerization.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Article
Refereed:Yes
Authors:Aleksanian, Samuel and Khorsand, Behnoush and Schmidt, Rolf and Oh, Jung Kwon
Journal or Publication:Polymer Chemistry
Date:2012
Digital Object Identifier (DOI):10.1039/C2PY20154B
Keywords:block copolymer micelles, stimuli-responsive, drug delivery, controlled radical polymerization, enhanced release
ID Code:978148
Deposited By: DAVID MACAULAY
Deposited On:10 Jan 2014 19:33
Last Modified:18 Jan 2018 17:46
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Downloads per month over past year

Back to top Back to top