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Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

Title:

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

Gouin, Jean-Philippe, Zhou, Q. Q., Booij, L., Boivin, M., Côté, S. M., Hébert, M., Ouellet-Morin, I., Szyf, M., Tremblay, R. E., Turecki, G. and Vitaro, F. (2017) Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness. Scientific Reports, 7 (7446). pp. 1-14. ISSN 2045-2322

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Official URL: http://dx.doi.org/10.1038/s41598-017-07950-x

Abstract

Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as a molecular mechanism underlying the increased risk of mental disorder associated with early life adversity (ELA). The goal of this study was to examine the association of ELA with oxytocin receptor gene (OXTR) methylation among young adults. Drawing from a 21-year longitudinal cohort, we compared adulthood OXTR methylation frequency of 46 adults (23 males and 23 females) selected for high or low ELA exposure based on childhood socioeconomic status and exposure to physical and sexual abuse during childhood and adolescence. Associations between OXTR methylation and teacher-rated childhood trajectories of anxiousness were also assessed. ELA exposure was associated with one significant CpG site in the first intron among females, but not among males. Similarly, childhood trajectories of anxiousness were related to one significant CpG site within the promoter region among females, but not among males. This study suggests that females might be more sensitive to the impact of ELA on OXTR methylation than males.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Gouin, Jean-Philippe and Zhou, Q. Q. and Booij, L. and Boivin, M. and Côté, S. M. and Hébert, M. and Ouellet-Morin, I. and Szyf, M. and Tremblay, R. E. and Turecki, G. and Vitaro, F.
Journal or Publication:Scientific Reports
Date:7 August 2017
Funders:
  • Quebec Network on Suicide, Mood Disorders, and Related Disorders
  • Canadian Institutes of Health Research
  • Social Sciences and Humanities Research Council of Canada
  • Fonds de Recherche du Québec- Santé
  • Canada Research Chair Secretariat
  • CIHR-GSK chair in pharmacology
  • Concordia Open Access Author Fund
Digital Object Identifier (DOI):10.1038/s41598-017-07950-x
ID Code:982751
Deposited By: DANIELLE DENNIE
Deposited On:11 Aug 2017 14:46
Last Modified:18 Jan 2018 17:55
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