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Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula

Title:

Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula

Chaudhri, Nadia ORCID: https://orcid.org/0000-0003-4217-4044, Cofresí, Roberto U., Grote, Dylan J., Viet Thanh Le, Eric, Monfils, Marie-H., Gonzales, Rueben A. and Lee, Hongjoo J. (2018) Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula. Alcohol . ISSN 07418329 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.alcohol.2018.08.004

Abstract

Alcohol self-administration produces brain and behavior adaptations that facilitate a progressive loss of control over drinking and contribute to relapse. One possible adaptation is the ability of antecedent environmental stimuli that are consistently paired with alcohol to trigger alcohol seeking behaviors. We previously modeled this adaptation in rats using a Pavlovian conditioning procedure in which illumination of a houselight preceded the presentation of a sipper tube that produced unsweetened alcohol when licked. However, in our previous work we did not demonstrate whether this adaptation represented a consequence of repeated exposure to alcohol or the houselight, or whether it was the consequence of associative learning and memory. Thus, in the present study, we tested the associative basis of alcohol seeking in response to houselight illumination in our task using adult male rats that were not food or water deprived and were not dependent on alcohol. Separate groups of rats received houselight illumination that was explicitly paired or unpaired with presentation of the retractable sipper that provided access to unsweetened alcohol. Our primary dependent variable was appetitive alcohol-directed behavior: the frequency of movement toward and interaction with the hole in the wall of the chamber through which the sipper was presented during the period of houselight illumination trial before each sipper presentation. However, we also analyzed consummatory sipper licking behavior and blood ethanol concentration in the same rats. Finally, we explored the brain basis of cue-elicited alcohol seeking using c-Fos immunohistochemistry. Our findings confirmed the associative basis of cue-elicited alcohol seeking in our paradigm and mapped these onto the insular cortex, suggesting a role for this brain region in early stages of brain and behavior adaptation to regular alcohol use

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Chaudhri, Nadia and Cofresí, Roberto U. and Grote, Dylan J. and Viet Thanh Le, Eric and Monfils, Marie-H. and Gonzales, Rueben A. and Lee, Hongjoo J.
Journal or Publication:Alcohol
Date:2018
Funders:
  • NIH NIAAA R37AA11852
  • NIH NIAAA T32AA007471
  • NIHM R01MH091147
  • CIHR MOP-137030
  • University of Texas undergraduate research fellowship
Digital Object Identifier (DOI):10.1016/j.alcohol.2018.08.004
Keywords:Cues; Alcohol seeking; Pavlovian conditioning; Low dose alcohol; Fos
ID Code:984201
Deposited By: ALINE SOREL
Deposited On:27 Aug 2018 16:32
Last Modified:17 Aug 2019 00:00

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