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Regional adiposity and markers of inflammation in pre-school age children

Title:

Regional adiposity and markers of inflammation in pre-school age children

Delaney, Kerri Z. ORCID: https://orcid.org/0000-0003-3937-3317, Vanstone, Catherine A., Weiler, Hope A. and Santosa, Sylvia ORCID: https://orcid.org/0000-0001-5814-6086 (2018) Regional adiposity and markers of inflammation in pre-school age children. Scientific Reports, 8 (1). ISSN 2045-2322

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Official URL: http://dx.doi.org/10.1038/s41598-018-33054-1

Abstract

In adults, upper body fat partially increases metabolic disease risk through increasing systemic inflammation. Our objective was to determine if this relationship exists in preschool-aged children. A subset of children (n = 71, 35 males), 3.7 ± 1.0 y, were studied from n = 515 children recruited from randomly selected daycares in Montréal, QC. According to WHO charts for 2–5 y, 49 children were healthy weight (HW) and 21 were overweight (OW). Adiposity was determined through dual-energy x-ray absorptiometry. Blood concentrations of C-reactive protein (CRP) and tumour necrosis factor alpha (TNFα) were determined via enzyme-linked immunosorbent and multiplex assays, respectively. OW children had higher (p = 0.03) android:gynoid ratio 0.50 ± 0.09 compared to HW children 0.56 ± 0.12, indicating excess fat was predominantly stored in the abdominal depot. CRP was higher (p = 0.01) in OW children 1.45 ± 2.02 mg/L compared to HW 0.74 ± 1.38 mg/L. Percent fat was correlated with CRP (r = 0.32; p < 0.01) and TNFα (r = 0.25; p = 0.04) concentrations. CRP also correlated with android adiposity (r = 0.24; p = 0.04) and TNFα correlated with gynoid adiposity (r = 0.24; p = 0.04). We observed that greater adiposity is associated with higher systemic inflammation in pre-school aged children. Future longitudinal studies are needed to understand the long term consequences of excess total and regional body fat in young children.

Divisions:Concordia University > Faculty of Arts and Science > Health, Kinesiology and Applied Physiology
Item Type:Article
Refereed:Yes
Authors:Delaney, Kerri Z. and Vanstone, Catherine A. and Weiler, Hope A. and Santosa, Sylvia
Journal or Publication:Scientific Reports
Date:2018
Funders:
  • Concordia Open Access Author Fund
  • The Dairy Farmers of Canada
  • The Canada Foundation for Innovation
  • The Beef Information Council
Digital Object Identifier (DOI):10.1038/s41598-018-33054-1
ID Code:984682
Deposited By: KRISTA ALEXANDER
Deposited On:14 Nov 2018 14:18
Last Modified:14 Nov 2018 14:18

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