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Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length

Title:

Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length

Huang, Yi, Onn Siong, Yim, San Lai, Poh, Yu, Rongjun, Hong Chew, Soo, Gwee, Xinyi, Shwe Zin Nyunt, Ma, Gao, Qi, Ng, Tze Pin, Ebstein, Richard P. and Gouin, Jean-Philippe (2019) Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length. Psychoneuroendocrinology . ISSN 03064530 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.psyneuen.2019.01.015

Abstract

In a rapidly greying world, the notion that some individuals maintain successful aging trajectories, viz. high physical, cognitive, emotional, and social functioning in older age, is increasingly germane. Biomarkers of such successful aging are increasingly sought. Leukocyte telomere length (LTL), an emerging yardstick of cellular aging that is influenced by but distinct from chronological age, may also be associated to successful aging. Furthermore, given that socio-economic status (SES) influences successful aging trajectories, socioeconomic status may also moderate the association between chronological age and LTL. The goals of this study are to examine 1) whether successful aging is associated with LTL; 2) whether successful aging accounts for age-related LTL and 3) whether low SES moderates the effect of age on LTL. Singaporean Chinese (n = 353) aged 65-80 completed a multidimensional assessment of successful aging and provided blood samples for LTL analysis. Results show that LTL negatively correlates with chronological age and positively correlates with successful aging. Successful aging mediates the association between chronological age and LTL. Moderated mediation analyses show that lower SES is associated with stronger negative associations of chronological age with successful aging and LTL. Moreover, the cognitive functioning dimension of successful aging is uniquely associated with LTL and its association with chronological age is moderated by SES. This study provides evidence that among older Singaporean Chinese with lower SES, declines in successful aging and in cognitive functioning are linked to age-related LTL shortening and hence to accelerated aging at the cellular level.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Huang, Yi and Onn Siong, Yim and San Lai, Poh and Yu, Rongjun and Hong Chew, Soo and Gwee, Xinyi and Shwe Zin Nyunt, Ma and Gao, Qi and Ng, Tze Pin and Ebstein, Richard P. and Gouin, Jean-Philippe
Journal or Publication:Psychoneuroendocrinology
Date:17 January 2019
Funders:
  • Singapore Ministry of Education’s Academic Research Fund Tier 2 grant MOE2013-T2-1-048
  • Biomedical Research Council (Grant BMRC/08/1/21/19/567)
  • National Medical Research Council (NMRC/CIRG/1409/2014)
  • Canada Research Chair Secretariat
Digital Object Identifier (DOI):10.1016/j.psyneuen.2019.01.015
ID Code:984959
Deposited By: MONIQUE LANE
Deposited On:31 Jan 2019 16:55
Last Modified:31 Jan 2019 16:55

References:

N.E. Adler, J. Stewart Health disparities across the lifespan: Meaning, methods, and mechanisms Ann. N. Y. Acad. Sci. (2010)

Y. Arai, T. Sasaki, N. Hirose Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: Part 2 Honshu Japan. Mech. Ageing Dev., 165 (2017), pp. 80-85

E.H. Blackburn, E.S. Epel, J. Lin Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection Science, 350 (80-.) (2015), pp. 1193-1198

L. Brown, B. Needham, J. Ailshire Telomere Length Among Older U.S. Adults: Differences by Race/Ethnicity, Gender, and Age J. Aging Health, 29 (2017), pp. 1350-1366

L.E. Carlson, T.L. Beattie, J. Giese-Davis, P. Faris, R. Tamagawa, L.J. Fick, E.S. Degelman, M. Speca Mindfulness-based cancer recovery and supportive-expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors Cancer, 121 (2015), pp. 476-484

J.E. Carroll, A.V. Diez Roux, A.L. Fitzpatrick, T. Seeman Low social support is associated with shorter leukocyte telomere length in late life: Multi-ethnic study of atherosclerosis Psychosom. Med., 75 (2013), pp. 171-177

R.M. Cawthon Telomere length measurement by a novel monochrome multiplex quantitative PCR method Nucleic Acids Res., 37 (2009)

C.R. Chittleborough, F.E. Baum, A.W. Taylor, J.E. Hiller A life-course approach to measuring socioeconomic position in population health surveillance systems J. Epidemiol. Community Health. (2006)

K Christensen, G Doblhammer, R Rau, JW Vaupel Ageing populations: the challenges ahead Lancet, 374 (9696) (2009), pp. 1196-1208

T.D. Cosco, a M. Prina, J. Perales, B.C.M. Stephan, C. Brayne Operational definitions of successful aging: A systematic review Int. Psychogeriatrics, 26 (2013), pp. 1-9

S.M. Darrow, J.E. Verhoeven, D. Révész, D. Lindqvist, B.W.J.H. Penninx, K.L. Delucchi, O.M. Wolkowitz, C.A. Mathews The Association between Psychiatric Disorders and Telomere Length: A Meta-Analysis Involving 14,827 Persons Psychosom. Med. (2016) I.J.

Deary, J. Corley, A.J. Gow, S.E. Harris, L.M. Houlihan, R.E. Marioni, L. Penke, S.B.Rafnsson, J.M. Starr Age-associated cognitive decline Br Med Bull., 92 (2009), pp. 135-152

C.A. Depp, D.V. Jeste Definitions and predictors of successful aging: A comprehensive review of larger quantitative studies Am. J. Geriatr. Psychiatry. (2006)

G. Der, G.D. Batty, M. Benzeval, I.J. Deary, M.J. Green, L. McGlynn, A. McIntyre, T. Robertson, P.G. Shiels Is Telomere Length a Biomarker for Aging: Cross-Sectional Evidence from the West of Scotland? PLoS One, 7 (2012)

L. Feng, M.S. Chong, W.S. Lim, T.P. Ng The modified mini-mental state examination test: Normative data for Singapore Chinese older adults and its performance in detecting early cognitive impairment Singapore Med. J., 53 (2012), pp. 458-462

M.F. Folstein, S.E. Folstein, P.R. McHugh, M. Roth, M.B. Shapiro, F. Post, B. Lofving, J.Ingles, E. Withers, J. Hinton, H. Halstead, F. Post, L.G. Kiloh “Mini-mental state” A practical method for grading the cognitive state of patients for the clinician J. Psychiatr. Res., 12 (1975), pp. 189-198

Government of Singapore. Housing and Development Board Annual Report 2016/2017: Key Statistics https://www.hdb.gov.sg/cs/infoweb/about-us/news-and publications/annual-reports (2017) (accessed 19 July 2018)

T.L. Gruenewald, S. Cohen, K.A. Matthews, R. Tracy, T.E. Seeman Association of socioeconomic status with inflammation markers in black and white men and women in the Coronary Artery Risk Development in Young Adults (CARDIA) study Soc. Sci. Med., 69 (2009), pp. 451-459

S.E. Harris, C. Martin-Ruiz, T. von Zglinicki, J.M. Starr, I.J. Deary Telomere length and aging biomarkers in 70-year-olds: The Lothian Birth Cohort 1936 Neurobiol. Aging, 33 (2012)

A.F. Hayes Introduction to mediation, moderation, and conditional process analysis: A regression-based approach Guilford Publications (2017)

J. Henrich, S.J. Heine, A. Norenzayan Most people are not WEIRD Behav. Brain Sci., 33 (2010), pp. 61-83

J.S. House, J.M. Lepkowski, a M. Kinney, R.P. Mero, R.C. Kessler, a R. Herzog The social stratification of aging and health J. Health Soc. Behav., 35 (1994), pp. 213-234

H.C. Hsu, B.L. Jones Multiple trajectories of successful aging of older and younger cohorts Gerontologist, 52 (2012), pp. 843-856

Y. Hu, H. Pikhart, A. Pajak, R. Kubínová, S. Malyutina, A. Besala, A. Peasey, M. Marmot, M.Bobak Education, material condition and physical functioning trajectories in middle-aged and older adults in Central and Eastern Europe: A cross-country comparison J. Epidemiol. Community Health, 70 (2016), pp. 1128-1135

E.L. Idler, Y. Benyamini Self-Rated Health and Mortality : A Review of Twenty-Seven Community Studies Author ( s ): Ellen L. Idler and Yael Benyamini Source J. Heal. Soc. Behav., 38 (1997), pp. 21-37

K.C. Insel, C.J. Merkle, C.P. Hsiao, A.N. Vidrine, D.W. Montgomery Biomarkers for cognitive aging part I: Telomere length, blood pressure and cognition among individuals with hypertension Biol. Res. Nurs., 14 (2012), pp. 124-132

D. Janicki-Deverts, S. Cohen, K.A. Matthews, M.D. Gross, D.R. Jr. Jacobs Socioeconomic status, antioxidant micro nutrients, and correlates of oxidative damage: The coronary artery risk development in young adults (CARDIA) study Psychosom. Med. (2009)

Kassebaum, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancies (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 Lancet, 388 (2016), pp. 1603-1658

A.A.L. Kok, M.J. Aartsen, D.J.H. Deeg, M. Huisman Capturing the Diversity of Successful Aging: An Operational Definition Based on 16 Year Trajectories of Functioning Gerontologist, 57 (2017), pp. 240-251

N. Krieger, D.R. Williams, N.E. Moss Measuring Social Class in US Public Health Research: Concepts, Methodologies, and Guidelines Annu. Rev. Public Health, 18 (1997), pp. 341-378

M.P. Lawton, E.M. Brody Assessment of older people: self-maintaining and instrumental activities of daily living Gerontologist, 9 (3) (1969), pp. 179-186

J. Lin, J. Cheon, R. Brown, M. Coccia, E. Puterman, K. Aschbacher, E. Sinclair, E. Epel, E.H.Blackburn Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes J. Immunol. Res., 2016 (2016)

P.P.J. Lim, L.L. Ng, P.C. Chiam, P.S. Ong, F.T.S. Ngui, S. Sahadevan Validation and comparison of three brief depression scales in an elderly Chinese population Int. J. Geriatr. Psychiatry, 15 (2000), pp. 824-830

J. Lyu, J.A. Burr Socioeconomic Status Across the Life Course and Cognitive Function among Older Adults: An Examination of the Latency, Pathways, and Accumulation Hypotheses J. Aging Health, 28 (2016), pp. 40-67

J.P. Mackenbach, I. Stirbu, A.-J.R. Roskam, M.M. Schaap, G. Menvielle, M. Leinsalu, A.E. Kunst, R. De Vogli, D. Gimeno, M. Kivimaki Socioeconomic inequalities in health in 22 European countries N. Engl. J. Med., 358 (2008), pp. 2468-2481

M. Maggio, J.M. Guralnik, D.L. Longo, L. Ferrucci Interleukin-6 in aging and chronic disease: A magnificent pathway Journals Gerontol. - Ser. A Biol. Sci. Med. Sci. (2006)

C. Martin-Ruiz, H.O. Dickinson, B. Keys, E. Rowan, R.A. Kenny, T. Von Zglinicki Telomere length predicts poststroke mortality, dementia, and cognitive decline Ann. Neurol., 60 (2006), pp. 174-180

A. Muezzinler, A.K. Zaineddin, H. Brenner A systematic review of leukocyte telomere length and age in adults Ageing Res Rev, 12 (2013), pp. 509-519

M. Niti, K.B. Yap, E.H. Kua, C.H. Tan, T.P. Ng Physical, social and productive leisure activities, cognitive decline and interaction with APOE-(epsilon)4 genotype in Chinese older adults Int. Psychogeriatrics, 20 (2008), pp. 237-251

O.T. Njajou, W.-C. Hsueh, E.H. Blackburn, A.B. Newman, S.-H. Wu, R. Li, E.M. Simonsick, T.M. Harris, S.R. Cummings, R.M. Cawthon Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study J. Gerontol. A. Biol. Sci. Med. Sci., 64 (2009), pp. 860-864

T.P. Ng, B.F. Broekman, M. Niti, X. Gwee, E.H. Kua Determinants of successful aging using a multidimensional definition among Chinese elderly in Singapore Am. J. Geriatr. Psychiatry., 17 (2009), pp. 407 416

D. Ornish, J. Lin, J.M. Chan, E. Epel, C. Kemp, G. Weidner, R. Marlin, S.J. Frenda, M.J.M.Magbanua, J. Daubenmier, I. Estay, N.K. Hills, N. Chainani-Wu, P.R. Carroll, E.H. Blackburn Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study Lancet Oncol., 14 (2013), pp. 1112-1120

H.P. Phua, A.V Chua, S. Ma, D. Heng, S.K. Chew Singapore’s burden of disease and injury Singapore Med J, 50 (2009), pp. 468-478

R.A Pruchno, M. Wilson-Genderson A Longitudinal Examination of the Effects of Early Influences and Midlife Characteristics on Successful Aging J. Gerontol. B. Psychol. Sci. Soc. Sci., 70 (2014), pp. 1-9

R.A. Pruchno, M. Wilson-Genderson, F. Cartwright A Two-Factor Model of Successful Aging Journals Gerontol. Ser. B Psychol. Sci. Soc. Sci., 65B (2010), pp. 671-679

L. Rask, L. Bendix, M. Harbo, B. Fagerlund, E.L. Mortensen, M.J. Lauritzen, M. Osler Cognitive change during the life course and leukocyte telomere length in late middle-aged men Front. Aging Neurosci., 8 (2016)

J.W. Rowe, R.L. Kahn Successful aging Gerontologist, 37 (1997), pp. 433-440

I. Shalev, S. Entringer, P.D. Wadhwa, O.M. Wolkowitz, E. Puterman, J. Lin, E.S. Epel Stress and telomere biology: A lifespan perspective Psychoneuroendocrinology, 38 (2013), pp. 1835-1842

P.G. Shiels, L.M. McGlynn, A. MacIntyre, P.C.D. Johnson, G.D. da Batty, H. Burns, J.Cavanagh, K.A. Deans, I. Ford, A. McConnachie, A. McGinty, J.S. McLean, K. Millar, N. Sattar, C.Tannahill, Y.N. Velupillai, C.J. Packard Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid Cohort. PLoS One, 6 (2011)

L.B. Signorello, S.S. Cohen, D.R. Williams, H.M. Munro, M.K. Hargreaves, W.J. Blot Socioeconomic status, race, and mortality: A prospective cohort study Am. J. Public Health, 104 (2014), pp. e98 e107

S. Sindi, T. Ngandu, I. Hovatta, I. K’areholt, R. Antikainen, T. Hänninen, E. Levälahti, T.Laatikainend, J. Lindström, T. Paajanen, M. Peltonen, D.S. Khalsa, B. Wolozin, T. Strandberg, J.Tuomilehto, H. Soininen, M. Kivipelto, A. Solomon Baseline telomere length and effects of a multidomain lifestyle intervention on cognition: The FINGER randomized controlled trial J. Alzheimer’s Dis., 59 (2017), pp. 1459-1470

D.F. Terry, V.G. Nolan, S.L. Andersen, T.T. Perls, R. Cawthon Association of longer telomeres with better health in centenarians J. Gerontol. A. Biol. Sci. Med. Sci., 63 (2008), pp. 809-812 A.M. Valdes, I.J. Deary, J. Gardner, M. Kimura, X. Lu, T.D. Spector, A. Aviv, L.F. Cherkas Leukocyte telomere length is associated with cognitive performance in healthy women Neurobiol. Aging, 31 (2010), pp. 986-992

K. Yaffe, K. Lindquist, M. Kluse, R. Cawthon, T. Harris, W.C. Hsueh, E.M. Simonsick, L. Kuller, R. Li, H.N. Ayonayon, S.M. Rubin, S.R. Cummings Telomere length and cognitive function in community dwelling elders: Findings from the Health ABC Study Neurobiol. Aging, 32 (2011), pp. 2055-2060
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