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Drosophila for drug discovery: useful tool or wishful thinking?

Title:

Drosophila for drug discovery: useful tool or wishful thinking?

Gamberi, Chiara ORCID: https://orcid.org/0000-0002-7122-6491 (2018) Drosophila for drug discovery: useful tool or wishful thinking? Drosophila Information Service, 101 . pp. 108-110.

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Abstract

"In the quest for new effective drugs there is the push for faster ways to identify active lead compounds to develop and validate in drug discovery pipelines. Cell culture-based screens are easy to run and can be both standardized and automated to perform efficient high-throughput screens. Combined with the large available compound libraries, they can be useful to identify leads. However, many of such leads have been found to fail in the subsequent validation steps, where system complexity increases, with many compounds revealing as toxic to a multicellular organism or unable to penetrate the target organs.

Flies are increasingly and successfully being used for pharmacological studies..."

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Refereed:Yes
Authors:Gamberi, Chiara
Journal or Publication:Drosophila Information Service
Date:December 2018
ID Code:985013
Deposited By: CHIARA GAMBERI
Deposited On:26 Feb 2019 20:03
Last Modified:26 Feb 2019 20:03
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References:

Freires, I.A., J. De Cassia Orlandi Sardi, and R. Dias De Castro 2016, Pharm. Res.34(4): 681-686. doi:10.1007/s11095-016-2069-z;

Gamberi, C. (corr.), D.R. Hipfner, M. Trudel, and W.D. Lubell 2017, PLoS Genet. 13(4): e1006694. doi: 10.1371/journal.pgen.1006694;

Pandey, U.B., and C.D. Nichols 2011, Pharmacol. Rev.63: 411–436; Strange, K., 2016, ILAR Journal 57(2): 133–143;

Zhou, S., S.E. Luoma, G.E. St Armour, E. Thakkar, T.F.C. Mackay, and R.R.H. Anholt 2017, PLoS Genet. 13(7): e1006907. doi: 10.1371/journal.pgen.1006907;

Ziehm, M., S. Kaur, D.K. Ivanov, P.J. Ballester, D. Marcus, L. Partridge, and J.M. Thornton 2017, Aging Cell, doi: 10.1111/acel.12626
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