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Cortical reactivations during sleep spindles following declarative learning

Title:

Cortical reactivations during sleep spindles following declarative learning

Jegou, Aude, Schabus, Manuel, Gosseries, Olivia, Dahmen, Brigitte, Albouy, Geneviève, Desseilles, Martin, Sterpenich, Virginie, Phillips, Christophe, Maquet, Pierre, Grova, Christophe and Dang-Vu, Thien Thanh (2019) Cortical reactivations during sleep spindles following declarative learning. NeuroImage . ISSN 10538119 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.neuroimage.2019.03.051

Abstract

Increasing evidence suggests that sleep spindles are involved in memory consolidation, but few studies have investigated the effects of learning on brain responses associated with spindles in humans. Here we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) during sleep to assess haemodynamic brain responses related to spindles after learning. Twenty young healthy participants were scanned with EEG/fMRI during (i) a declarative memory face sequence learning task, (ii) subsequent sleep, and (iii) recall after sleep (learning night). As a control condition an identical EEG/fMRI scanning protocol was performed after participants over-learned the face sequence task to complete mastery (control night). Results demonstrated increased responses in the fusiform gyrus both during encoding before sleep and during successful recall after sleep, in the learning night compared to the control night. During sleep, a larger response in the fusiform gyrus was observed in the presence of fast spindles during the learning as compared to the control night. Our findings support a cortical reactivation during fast spindles of brain regions previously involved in declarative learning and subsequently activated during memory recall, thereby promoting the cortical consolidation of memory traces.

Divisions:Concordia University > Faculty of Arts and Science > Health, Kinesiology and Applied Physiology
Item Type:Article
Refereed:Yes
Authors:Jegou, Aude and Schabus, Manuel and Gosseries, Olivia and Dahmen, Brigitte and Albouy, Geneviève and Desseilles, Martin and Sterpenich, Virginie and Phillips, Christophe and Maquet, Pierre and Grova, Christophe and Dang-Vu, Thien Thanh
Journal or Publication:NeuroImage
Date:28 March 2019
Funders:
  • Belgian National Funds for Scientific Research
  • Natural Sciences and Engineering Research Council of Canada
  • Canadian Institutes of Health Research
  • Fonds de Recherche du Québec – Santé
  • Erwin Schrödinger fellowship of the Austrian Science Fund
Digital Object Identifier (DOI):10.1016/j.neuroimage.2019.03.051
Keywords:Consolidation; EEG/fMRI; Memory; Oscillations; Replay; Sleep
ID Code:985153
Deposited By: MICHAEL BIRON
Deposited On:08 Apr 2019 18:09
Last Modified:08 Apr 2019 18:09

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