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A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature


A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature

Desharnais, Brigitte ORCID: https://orcid.org/0000-0001-7373-656X, Dazé, Yann, Huppertz, Laura M., Mireault, Pascal and Skinner, Cameron D. (2017) A case of fatal idiosyncratic reaction to the designer drug 3,4-methylenedioxypyrovalerone (MDPV) and review of the literature. Forensic Science, Medicine and Pathology, 13 . pp. 350-354. ISSN 1547-769X

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Official URL: https://doi.org/10.1007/s12024-017-9894-1


The stimulant designer drug 3,4-methylenedioxypyrovalerone (MDPV) was first synthesized by Boehringer Ingelheim in 1969 and introduced on the black market in 2006. Only a small number of fatal intoxication cases have been reported in the literature, all with significant blood MDPV concentrations. In this report, we describe one fatality attributed to an idiosyncratic reaction to MDPV. The victim displayed agitation, violent behavior and delirium followed by cardiac arrest. Hyperthermia was observed at the hospital. The MDPV cardiac and femoral blood concentrations were 6 ng/mL. The presence of excited delirium syndrome and MDPV, a drug with a pharmacology similar to cocaine, leads to the conclusion that the victim suffered a fatal adverse reaction to MDPV. This is the first published case of idiosyncratic reaction to MDPV.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Article
Authors:Desharnais, Brigitte and Dazé, Yann and Huppertz, Laura M. and Mireault, Pascal and Skinner, Cameron D.
Journal or Publication:Forensic Science, Medicine and Pathology
Date:1 July 2017
  • Laboratoire de sciences judiciaires et de médecine légale
  • National Sciences and Engineering Research Council of Canada
  • Fonds de recherche du Québec - Nature et technologies
Digital Object Identifier (DOI):10.1007/s12024-017-9894-1
Keywords:MDPV, “bath salts”, Idiosyncratic reaction, Toxicology, Excited delirium, Adverse drug reaction
ID Code:986236
Deposited On:15 Jan 2020 20:45
Last Modified:15 Jan 2020 20:50
Related URLs:
Additional Information:This is a post-peer-review, pre-copyedit version of an article published in Forensic Science, Medicine and Pathology. The final authenticated version is available online at: https://doi.org/10.1007/s12024-017-9894-1


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