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The Longitudinal Associations Between Endothelial Function and Diabetes Type II and Diabetes Related Outcomes in People with No Major Non-Communicable Chronic Diseases: A Systematic Review

Title:

The Longitudinal Associations Between Endothelial Function and Diabetes Type II and Diabetes Related Outcomes in People with No Major Non-Communicable Chronic Diseases: A Systematic Review

Jamil, Mahrukh (2020) The Longitudinal Associations Between Endothelial Function and Diabetes Type II and Diabetes Related Outcomes in People with No Major Non-Communicable Chronic Diseases: A Systematic Review. Masters thesis, Concordia University.

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Abstract

Context: Endothelial function plays a very important role in controlling vascular tone, inflammatory responses, immune responses and haemostasis. It has been linked with the progression of diabetes type II in the literature, but it is still not known whether diabetes is a cause or consequence of endothelial dysfunction. Also, there are no systematic reviews available on this topic. Objective: To explore whether endothelial function is associated with type II diabetes and other diabetes related outcomes in apparently healthy participants with no non-communicable diseases using a systematic review. Data sources: PubMed, Scopus and Web of Science databases were searched, from inception to September 2019, for articles published in English and French. Search terms include synonyms of diabetes type II, HbA1c, endothelial function, flow-mediated dilation and finger plethysmography. Study selection: Longitudinal studies and cohort/placebo/control group of interventions studies with non-invasive endothelial function measures—flow mediated dilation (FMD) and reactive hyperemia index (RHI)—at the start of the study and a diagnosis of type II diabetes or any surrogate measure of diabetes at follow-up were included. Data Extraction: Data extraction and quality assessment using Newcastle-Ottawa scale for cohort studies were performed by the two reviewers independently. Data synthesis: Qualitative data synthesis was performed. Result: The search yielded 20141 retrieves, 12429 articles were obtained after deduplication, out of which 127 were screened for full text, 16 selected articles were used for data extraction and author’s contact. Four articles were included for final analysis. Three studies reported a non-significant relationship between endothelial function and fasting plasma glucose and HbA1c; whereas one study reported significant results for endothelial function and incidence of diabetes. Conclusion: The available evidence from this review did not show any statistically significant association between endothelial function (measured by FMD and RHI) at baseline and surrogate measures of diabetes type II (fasting blood glucose, HbA1c) but showed limited evidence(with only one article) that endothelial function at baseline is associated with the diagnosis of type II diabetes. More longitudinal studies with healthy participants having primary focus on the association are required to provide more evidence in this domain.

Divisions:Concordia University > Faculty of Arts and Science > Exercise Science
Concordia University > Faculty of Arts and Science > Health, Kinesiology and Applied Physiology
Item Type:Thesis (Masters)
Authors:Jamil, Mahrukh
Institution:Concordia University
Degree Name:M. Sc.
Program:Health and Exercise Science
Date:13 August 2020
Thesis Supervisor(s):Bacon, Simon
Keywords:Endothelial function, Diabetes type II, Longitudinal association, Flow mediated dilation, Reactive hyperemia index
ID Code:987261
Deposited By: mahrukh jamil
Deposited On:25 Nov 2020 16:40
Last Modified:25 Nov 2020 16:40
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References:

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