The rapid advances in Real-Time Location Systems (RTLSs), such as Ultra-Wideband (UWB) technology, provide opportunities to realize new types of multimedia environments. Taking advantage of the UWB technology, this research investigates how location information enhances multimedia environments by utilizing the relationship between the physical environment and its habitants. In this thesis, we present an approach, called UWB-based Responsive Multimedia Space (URMS), that combines near real-time location data with multimedia devices. This approach has three main parts: (1) the concept of URMS incorporating multimedia devices for the realization of a series of location-based events, (2) the requirements of the UWB system and multimedia devices for the development of URMS, and (3) the methods for the grid-based event selection, and continuous and smooth adjustment of location-based interaction based on distance. Furthermore, a touch user interface is proposed to define interactively multimedia events. In order to validate the proposed approach, a prototype system is developed and tested in two case studies.