The need to promote the application of computers in the healthcare industry, particularly through the adoption in Clinical Information Systems (CIS), is more important now than ever before. As the healthcare industry faces a big deficiency in Information and Communication Technology (ICT) applications, we believe that system developers have to follow appropriate methodologies so that the resulting software product in this application domain could be considered easy, both to learn and use, by direct end-users while remaining acceptable to all involved stakeholders and their dynamic needs. With this in mind, in this thesis, we have combined the use of workflow modeling, agile software development through eXtreme Programming (XP) and the principles and practices from User-Centered Design (UCD) to develop a component of CIS; namely, a nurses' module. The workflow model of the various processes in the organ transplant ward of a typical large hospital was acquired. From this, the Nursing Process was developed as an application exercise.