Individuals affected by depression describe a sever state of cognitive, emotional, and physical suffering, as well as immense solitude, a constant state of helplessness and hopelessness, self-doubt, and fear (Allen, 2006; Blake, 1995; Funder, 2001; Penden, 2000). The perception of the self becomes skewed to perseverate on negative cognitions (Allen, 2006), thus affecting the personality development of the individual. Reynolds (2000) states, that the psychological state of depression reduces motivation and alters one's self-concept, thereby sabotaging any attempt to combat depression. Through the use of art therapy, one is able to challenge negative beliefs and cognitions, increase competency and control, and re-create the self extending beyond habitual roles (McNiff, 1976). Thus, the following research is an exploration of the relationship between a life altered by Major Depressive Disorder (MDD), the transformation of personality, and the effects of art therapy as it existed for one woman. Through the use of artistic interventions Ginger was able to recognize the significant internal and external losses experienced within her life while simultaneously re-creating and re-affirming her personality.