Sustainability has been widely discussed from different points of view. Manufacturing is contributing a critical part of incompliance to environment and human rights in our modern society. While a lot of companies are seeking strategies to either promote corporation image or stimulate employees’ work passion, most of research and guidelines are focusing on how to measure the sustainability based on the cases from big firms. Most of manufacturing firms are medium and small sized, they are searching for a comprehensive and systematical way to implement sustainability practice step by step without using very experienced professionals. This thesis research is supplying a systematic framework for firms to achieve sustainability in manufacturing environment with the widely used problem solving tool Six Sigma. Inexperienced professionals will be able to implement the sustainability practice from defining problems to achieving leadership in sustainability. It has also supplied a case study where it illustrates how to customize the framework content based on individual needs.