This research paper asks the question: What is the role of Winnicott’s potential space in the therapeutic relationship in art therapy with children with who have been diagnosed with autism?  Using theoretical research methodology, a representative review of the literature was completed for seven topics encapsulated within this question: Winnicott’s potential space, the potential space in the therapeutic relationship, art therapy, the potential space in art therapy, autism, autism and the potential space, and finally, autism and art therapy.  Based on this information, it has been proposed that due to their challenges in connecting interpersonally with others, children with autism may not have the ability to make effective use of the potential space that is typically experienced with the primary caregiver during infant development.  Thus, the co-creation and effective use of the potential space within the therapeutic relationship in art therapy through the art materials and catered support of the art therapist is proposed as a focus of treatment for this population.  Positive experience of the potential space within the therapeutic relationship can foster an interpersonal connection, a sense of self, personal agency, awareness of others, and overall improved interpersonal skills in children with autism that can then be generalized to other relationships in their lives.