There has been a growing interest in location problems for their wide use in many areas, such as passive optical networks and logistics networks. However, as the papers appear in different literature, researchers usually do not take advantage of their mutual findings. We propose to bridge the gaps and therefore to propose efficient solutions schemes for two different applications. In the first application, our research goal is to investigate the FTTX (Fiber-to-the Home/Premises/Curb) passive optical network (PON) for the deployment of broadband access. We focus on designing the best possible architectures of FTTX hybrid PONs, which embraces both Time Division Multiplexing (TDM) and Wave Division Multiplexing (WDM) technology. A hybrid PON architecture is very efficient as it is not limited to any specific PON technology, rather it is flexible enough to deploy TDM/WDM technology depending on the type (i.e., unicast/multicast) and amount of traffic demand of the end-users. We investigate the optimized covering of a geographical area by a set of cost-effective hybrid PONs. We propose a novel network design optimization scheme for greenfield deployment of a set of hybrid PONs, in which all significant constraints are taken into account, e.g., type of traffic, attenuation, choice of splitting equipment. In the second application, we revisit the p-center location problem in the context of disruption events. We propose an optimized covering in the geographical area for a given number of customers and suppliers, ensuring each customer is assigned a primary supplier and a different backup supplier unless the primary supplier has a so-called fortified facility. However, the budget for facility fortification is limited and only few facilities can be fortified. We design an optimization model under the assumption of single event disruptions, and estimate accurately the required facility capacities while taking into account a sharing of the backup resources. We evaluate our proposed models and algorithms by a comprehensive set of numerical experiments, with some comparisons in each of these two applications. Conclusions are drawn in the last chapter.