Acheson, A., Mahler, S. V., Chi, H., & de Wit, H. (2006). Differential effects of nicotine on alcohol consumption in men and women. Psychopharmacology, 186, 54. doi:10.1007/s00213-006-0338-y Baldo, B. A., Daniel, R. A., Berridge, C. W., & Kelley, A. E. (2003). Overlapping distributions of orexin/hypocretin- and dopamine-β-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. The Journal of Comparative Neurology, 464, 220-237. doi:10.1002/cne.10783 Barrett, S. P., Tichauer, M., Leyton, M., & Pihl, R. O. (2006). Nicotine increases alcohol self-administration in non-dependent male smokers. Drug and Alcohol Dependence, 81, 197-204. doi:10.1016/j.drugalcdep.2005.06.009 Bongiovanni, M., & See, R. E. (2008). A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in rats. Pharmacology Biochemistry and Behavior, 89, 227-233. doi:10.1016/j.pbb.2007.12.019 Boyle, E. A., Li, Y. I., & Pritchard, J. K. (2017). An expanded view of complex traits: From polygenic to omnigenic. Cell, 169, 1177-1186. doi:10.1016/j.cell.2017.05.038 Budney, A. J., Higgins, S. T., Hughes, J. R., & Bickel, W. K. (1993). Nicotine and caffeine use in cocaine-dependent individuals. Journal of Substance Abuse, 5, 117-130. doi:10.1016/0899-3289(93)90056-H Cahill, K., Lindson-Hawley, N., Thomas, K. H., Fanshawe, T. R., & Lancaster, T. (2016). Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews, 5, CD006103. doi:10.1002/14651858.CD006103.pub7 Chaudhri, N., Caggiula, A. R., Donny, E. C., Booth, S., Gharib, M., Craven, L., . . . Sved, A. F. (2006). Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine. Psychopharmacology, 189, 27-36. doi:10.1007/s00213-006-0522-0 Clemens, K. J., Caillé, S., & Cador, M. (2010). The effects of response operandum and prior food training on intravenous nicotine self-administration in rats. Psychopharmacology, 211, 43-54. doi:10.1007/s00213-010-1866-z Coleman, P. J., Gotter, A. L., Herring, W. J., Winrow, C. J., & Renger, J. J. (2017). The discovery of suvorexant, the first orexin receptor drug for insomnia. Annual Review of Pharmacology and Toxicology, 57, 509-533. doi:10.1146/annurev-pharmtox-010716-104837 Cross, S. J., Lotfipour, S., & Leslie, F. M. (2017). Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse. The American Journal of Drug and Alcohol Abuse, 43, 171-185. doi:10.1080/00952990.2016.1209512 de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., . . . Sutcliffe, J. G. (1998). The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences, 95, 322-327. doi:10.1073/pnas.95.1.322 Elias, C. F., Saper, C. B., Maratos-Flier, E., Tritos, N. A., Lee, C., Kelly, J., . . . Elmquist, J. K. (1998). Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. The Journal of Comparative Neurology, 402, 442-459. doi:10.1002/(SICI)1096-9861(19981228)402:4<442::AID-CNE2>3.0.CO;2-R Ellis, J., Pediani, J. D., Canals, M., Milasta, S., & Milligan, G. (2006). Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Journal of Biological Chemistry, 281, 38812-38824. doi:10.1074/jbc.M602494200 Fadel, J., Pasumarthi, R., & Reznikov, L. R. (2005). Stimulation of cortical acetylcholine release by orexin A. Neuroscience, 130, 541-547. doi:10.1016/j.neuroscience.2004.09.050 Garcia, K. L. P., Lê, A. D., & Tyndale, R. F. (2014). Effect of food training and training dose on nicotine self-administration in rats. Behavioural Brain Research, 274, 10-18. doi:10.1016/j.bbr.2014.07.043 Gorelick, D. A., Simmons, M. S., Carriero, N., & Tashkin, D. P. (1997). Characteristics of smoked drug use among cocaine smokers. The American Journal on Addictions, 6, 237-245. doi:10.1111/j.1521-0391.1997.tb00403.x Grant, K. M., Kelley, S. S., Agrawal, S., Meza, J. L., Meyer, J. R., & Romberger, D. J. (2007). Methamphetamine use in rural midwesterners. The American Journal on Addictions, 16, 79-84. doi:10.1080/10550490601184159 Hirose, M., Egashira, S.-i., Goto, Y., Hashihayata, T., Ohtake, N., Iwaasa, H., . . . Yamada, K. (2003). N-Acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: The first orexin-2 receptor selective non-peptidic antagonist. Bioorganic & Medicinal Chemistry Letters, 13, 4497-4499. doi:10.1016/j.bmcl.2003.08.038 Hollander, J. A., Lu, Q., Cameron, M. D., Kamenecka, T. M., & Kenny, P. J. (2008). Insular hypocretin transmission regulates nicotine reward. Proceedings of the National Academy of Sciences, 105, 19480-19485. doi:10.1073/pnas.0808023105 Jäntti, M. H., Mandrika, I., & Kukkonen, J. P. (2014). Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors. Biochemical and Biophysical Research Communications, 445, 486-490. doi:10.1016/j.bbrc.2014.02.026 Kalejaiye, O., Bhatti, B. H., Taylor, R. E., & Tizabi, Y. (2013). Nicotine blocks the depressogenic effects of alcohol: Implications for drinking-smoking co-morbidity. Journal of drug and alcohol research, 2, 235709. doi:10.4303/jdar/235709 Kane, J. K., Parker, S. L., & Li, M. D. (2001). Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat. Neuroscience Letters, 298, 1-4. doi:10.1016/S0304-3940(00)01730-4 Kane, J. K., Parker, S. L., Matta, S. G., Fu, Y., Sharp, B. M., & Li, M. D. (2000). Nicotine up-regulates expression of orexin and its receptors in rat brain. Endocrinology, 141, 3623-3629. doi:10.1210/endo.141.10.7707 Kastin, A. J., & Akerstrom, V. (1999). Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. Journal of Pharmacology and Experimental Therapeutics, 289, 219-223. Khoo, S. Y.-S., McNally, G. P., & Clemens, K. J. (2017). The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS ONE, 12, e0173967. doi:10.1371/journal.pone.0173967 Kouri, E. M., McCarthy, E. M., Faust, A. H., & Lukas, S. E. (2004). Pretreatment with transdermal nicotine enhances some of ethanol’s acute effects in men. Drug and Alcohol Dependence, 75, 55-65. doi:10.1016/j.drugalcdep.2004.01.011 Kukkonen, J. P., & Leonard, C. S. (2014). Orexin/hypocretin receptor signalling cascades. British Journal of Pharmacology, 171, 314-331. doi:10.1111/bph.12324 Lê, A. D., Funk, D., Lo, S., & Coen, K. (2014). Operant self-administration of alcohol and nicotine in a preclinical model of co-abuse. Psychopharmacology, 231, 4019-4029. doi:10.1007/s00213-014-3541-2 Lerman, C., LeSage, M. G., Perkins, K. A., O'Malley, S. S., Siegel, S. J., Benowitz, N. L., & Corrigall, W. A. (2007). Translational research in medication development for nicotine dependence. Nature Reviews Drug Discovery, 6, 746-762. doi:10.1038/nrd2361 LeSage, M. G., Perry, J. L., Kotz, C. M., Shelley, D., & Corrigall, W. A. (2010). Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. Psychopharmacology, 209, 203-212. doi:10.1007/s00213-010-1792-0 Navarro, G., Quiroz, C., Moreno-Delgado, D., Sierakowiak, A., McDowell, K., Moreno, E., . . . McCormick, P. J. (2015). Orexin–corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. The Journal of Neuroscience, 35, 6639-6653. doi:10.1523/jneurosci.4364-14.2015 Nishizawa, D., Kasai, S., Hasegawa, J., Sato, N., Yamada, H., Tanioka, F., . . . Ikeda, K. (2015). Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Molecular Brain, 8, 50. doi:10.1186/s13041-015-0142-x Pasumarthi, R. K., & Fadel, J. (2008). Activation of orexin/hypocretin projections to basal forebrain and paraventricular thalamus by acute nicotine. Brain Research Bulletin, 77, 367-373. doi:10.1016/j.brainresbull.2008.09.014 Pasumarthi, R. K., & Fadel, J. (2010). Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. Journal of Neurochemistry, 113, 1023-1035. doi:10.1111/j.1471-4159.2010.06666.x Pasumarthi, R. K., Reznikov, L. R., & Fadel, J. (2006). Activation of orexin neurons by acute nicotine. European Journal of Pharmacology, 535, 172-176. doi:10.1016/j.ejphar.2006.02.021 Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998). Neurons containing hypocretin (orexin) project to multiple neuronal systems. The Journal of Neuroscience, 18, 9996-10015. Plaza-Zabala, A., Flores, Á., Maldonado, R., & Berrendero, F. (2012). Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal. Biological Psychiatry, 71, 214-223. doi:10.1016/j.biopsych.2011.06.025 Plaza-Zabala, A., Flores, A., Martin-Garcia, E., Saravia, R., Maldonado, R., & Berrendero, F. (2013). A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior. Neuropsychopharmacology, 38, 1724-1736. doi:10.1038/npp.2013.72 Plaza-Zabala, A., Martín-García, E., de Lecea, L., Maldonado, R., & Berrendero, F. (2010). Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. The Journal of Neuroscience, 30, 2300-2310. doi:10.1523/jneurosci.5724-09.2010 Rotter, A., Bayerlein, K., Hansbauer, M., Weiland, J., Sperling, W., Kornhuber, J., & Biermann, T. (2012). Orexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokers. Neuropsychobiology, 66, 126-133. doi:10.1159/000339457 Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., . . . Yanagisawa, M. (1998). Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585. doi:10.1016/s0092-8674(00)80949-6 Sakurai, T., Moriguchi, T., Furuya, K., Kajiwara, N., Nakamura, T., Yanagisawa, M., & Goto, K. (1999). Structure and function of human prepro-orexin gene. Journal of Biological Chemistry, 274, 17771-17776. doi:10.1074/jbc.274.25.17771 Simmons, S. J., Gentile, T. A., Mo, L., Tran, F. H., Ma, S., & Muschamp, J. W. (2016). Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats. Behavioural Brain Research, 314, 226-233. doi:10.1016/j.bbr.2016.07.053 Smith, R. J., See, R. E., & Aston-Jones, G. (2009). Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. European Journal of Neuroscience, 30, 493-503. doi:10.1111/j.1460-9568.2009.06844.x Taylor, M., Collin, S. M., Munafò, M. R., MacLeod, J., Hickman, M., & Heron, J. (2017). Patterns of cannabis use during adolescence and their association with harmful substance use behaviour: findings from a UK birth cohort. Journal of Epidemiology and Community Health. doi:10.1136/jech-2016-208503 The University of Texas Health Science Center. (2016). Role of the orexin receptor system in stress, sleep and cocaine use. Retrieved from clinicaltrials.gov/show/NCT02785406 Uslaner, J. M., Winrow, C. J., Gotter, A. L., Roecker, A. J., Coleman, P. J., Hutson, P. H., . . . Renger, J. J. (2014). Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement. Behavioural Brain Research, 269, 61-65. doi:10.1016/j.bbr.2014.04.012 Visscher, Peter M., Brown, Matthew A., McCarthy, Mark I., & Yang, J. (2012). Five years of GWAS discovery. The American Journal of Human Genetics, 90, 7-24. doi:10.1016/j.ajhg.2011.11.029 von der Goltz, C., Koopmann, A., Dinter, C., Richter, A., Rockenbach, C., Grosshans, M., . . . Kiefer, F. (2010). Orexin and leptin are associated with nicotine craving: A link between smoking, appetite and reward. Psychoneuroendocrinology, 35, 570-577. doi:10.1016/j.psyneuen.2009.09.005 Winrow, C. J., Tanis, K. Q., Reiss, D. R., Rigby, A. M., Uslaner, J. M., Uebele, V. N., . . . Renger, J. J. (2010). Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology, 58, 185-194. doi:10.1016/j.neuropharm.2009.07.008 Xu, T. R., Ward, R. J., Pediani, J. D., & Milligan, G. (2011). The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Biochemical Journal, 439, 171-183. doi:10.1042/bj20110230