Pipelines are subjected to many damaging agents, such as, earthquake, ground movement, and aging which are responsible for important financial expenses. Structural Health Monitoring (SHM) of civil structures using arrays of sensors is promising such that data form the monitoring systems enable us to trace the structural anomalies and performance for early treatments. The need for introducing faster and intelligent methods has helped researchers propose novel approaches for such monitoring procedures. In this study a new method is introduced for monitoring of surface pipelines used primarily for oil and gas. The framework takes the advantage of Gaussian Process Regression Method (GPRM) to create a probabilistic predictive model for damage detection and the subsequent localization of the defect. To this end, an isotropic pipeline is modeled numerically and validated with an experimental setup. Afterwards, the model is extended to the real-life application to establish a meta model. Damages are introduced as small holes at different locations (one at each time). The GPRM is used to map the system responses to the selected statistical features which are utilized as indicators for the existence of the damages and their locations. GPRM reveals more promising results compared with conventional regression analysis. It considers the uncertainties due to lack of observation. In addition, it is an updatable approach with having local effects on the model. In another words, it affects the model in the vicinity of new observations. Moreover, among selected statistical features, number of peaks greater than or equal to 20% and 60% of the maximum peak values show better results corresponding to damage localization. Also the curve length and correlation coefficient of the system response (induced signal) are found to be efficient for damage detection. The novel method has been validated with filed measurements and experimental data and found to work efficiently.