1. Kaput J, Goltz S, Blobel G (1982) Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor. Functional implications of the pre sequence for protein transport into mitochondria. J Biol Chem 257(24):15054–15058. 2. Suppanz IE, Wurm CA, Wenzel D, Jakobs S (2009) The m-AAA protease processes cytochrome c peroxidase preferentially at the inner boundary membrane of mitochondria. Mol Biol Cell 20(2):572–580. 3. Michaelis G, et al. (2005) Mitochondrial signal peptidases of yeast: The rhomboid peptidase Pcp1 and its substrate cytochrome C peroxidase. Gene 354:58–63. 4. Sels AA, Cocriamont C (1968) Induced conversion of a protein precursor into cytochrome C peroxidase during adaptation of yeast to oxygen. Biochem Biophys Res Commun 32(2):192–198. 5. Djavadi-Ohaniance L, Rudin Y, Schatz G (1978) Identification of enzymically inactive apocytochrome c peroxidase in anaerobically grown Saccharomyces cerevisiae. J Biol Chem 253(12):4402–4407. 6. Volkov AN, Nicholls P, Worrall JAR (2011) The complex of cytochrome c and cytochrome c peroxidase: The end of the road? Biochim Biophys Acta 1807(11):1482 1503. 7. Perrone GG, Tan S-X, Dawes IW (2008) Reactive oxygen species and yeast apoptosis. Biochim Biophys Acta 1783(7):1354–1368. 8. Kwon M, Chong S, Han S, Kim K (2003) Oxidative stresses elevate the expression of cytochrome c peroxidase in Saccharomyces cerevisiae. Biochim Biophys Acta 1623(1):1–5. 9. Jiang H, English AM (2006) Phenotypic analysis of the ccp1Delta and ccp1Deltaccp1W191F mutant strains of Saccharomyces cerevisiae indicates that cytochrome c peroxidase functions in oxidative-stress signaling. J Inorg Biochem 100(12):1996–2008. 10. Martins D, Kathiresan M, English AM (2013) Cytochrome c peroxidase is a mitochondrial heme-based H2O2 sensor that modulates antioxidant defense. Free Radic Biol Med 65:541–551. 11. Martins D, Titorenko VI, English AM (2014) Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer. Antioxid Redox Signal 21(10): 1490–1503. 12. Skulachev VP (1998) Cytochrome c in the apoptotic and antioxidant cascades. FEBS Lett 423(3):275–280. 13. Cohen G, Rapatz W, Ruis H (1988) Sequence of the Saccharomyces cerevisiae CTA1 gene and amino acid sequence of catalase A derived from it. Eur J Biochem 176(1): 159–163. 14. Hartig A, Ruis H (1986) Nucleotide sequence of the Saccharomyces cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase T. Eur J Biochem 160(3): 487–490. 15. Petrova VY, Drescher D, Kujumdzieva AV, Schmitt MJ (2004) Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem J 380(Pt 2):393–400. 16. Zimniak P, Hartter E, Woloszczuk W, Ruis H (1976) Catalase biosynthesis in yeast: Formation of catalase A and catalase T during oxygen adaptation of Saccharomyces cerevisiae. Eur J Biochem 71(2):393–398. 17. Kaput J, Brandriss MC, Prussak-Wieckowska T (1989) In vitro import of cytochrome c peroxidase into the intermembrane space: Release of the processed form by intact mitochondria. J Cell Biol 109(1):101–112. 18. Yaffe MP (2003) The cutting edge of mitochondrial fusion. Nat Cell Biol 5(6):497–499. 19. Dingwall C, Laskey RA (1986) Protein import into the cell nucleus. Annu Rev Cell Biol 2:367–390. 20. Whelan SP, Zuckerbraun BS (2013) Mitochondrial signaling: Forwards, backwards, and in between. Oxid Med Cell Longev 2013:351613. 21. Feissner R, Xiang Y, Kranz RG (2003) Chemiluminescent-based methods to detect subpicomole levels of c-type cytochromes. Anal Biochem 315(1):90–94. 22. Mesquita A, et al. (2010) Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. Proc Natl Acad Sci USA 107(34):15123–15128. 23. Goldberg AA, et al. (2009) Effect of calorie restriction on the metabolic history of chronologically aging yeast. Exp Gerontol 44(9):555–571. 24. Burke PV, Raitt DC, Allen LA, Kellogg EA, Poyton RO (1997) Effects of oxygen concentration on the expression of cytochrome c and cytochrome c oxidase genes in yeast. J Biol Chem 272(23):14705–14712. 25. Wright RM, Poyton RO (1990) Release of two Saccharomyces cerevisiae cytochrome genes, COX6 and CYC1, from glucose repression requires the SNF1 and SSN6 gene products. Mol Cell Biol 10(3):1297–1300. 26. Erman JE, Yonetani T (1975) A kinetic study of the endogenous reduction of the oxidized sites in the primary cytochrome c peroxidase-hydrogen peroxide compound. Biochim Biophys Acta 393(2):350–357. 27. Paul J, Chen W, Ohlsson P-I, Smith M (1998) Heme transfer reactions: An important prerequisite for synthetic oxygen carriers. Turkish J Chem 22(2):103–108. 28. Hargrove MS, et al. (1994) Stability of myoglobin: A model for the folding of heme proteins. Biochemistry 33(39):11767–11775. 29. Adams PA (1977) The kinetics of the recombination reaction between apomyoglobin and alkaline haematin. Biochem J 163(1):153–158. 30. Fox T, Tsaprailis G, English AM (1994) Fluorescence investigation of yeast cytochrome c peroxidase oxidation by H2O2 and enzyme activities of the oxidized enzyme. Biochemistry 33(1):186–191. 31. Tsaprailis G, English AM (2003) Different pathways of radical translocation in yeast cytochrome c peroxidase and its W191F mutant on reaction with H(2)O(2) suggest an antioxidant role. J Biol Inorg Chem 8(3):248–255. 32. Yogev O, Naamati A, Pines O (2011) Fumarase: A paradigm of dual targeting and dual localized functions. FEBS J 278(22):4230–4242. 33. Tsaprailis G, Chan DW, English AM (1998) Conformational states in denaturants of cytochrome c and horseradish peroxidases examined by fluorescence and circular dichroism. Biochemistry 37(7):2004–2016. 34. Dumont ME, Cardillo TS, Hayes MK, Sherman F (1991) Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol 11(11):5487–5496. 35. Fisher WR, Taniuchi H, Anfinsen CB (1973) On the role of heme in the formation of the structure of cytochrome c. J Biol Chem 248(9):3188–3195. 36. Hörtner H, et al. (1982) Regulation of synthesis of catalases and iso-1-cytochrome c in Saccharomyces cerevisiae by glucose, oxygen and heme. Eur J Biochem 128(1): 179–184. 37. Woloszczuk W, Sprinson DB, Ruis H (1980) The relation of heme to catalase apoprotein synthesis in yeast. J Biol Chem 255(6):2624–2627. 38. Uchida K, Kawakishi S (1994) Identification of oxidized histidine generated at the active site of Cu,Zn-superoxide dismutase exposed to H2O2. Selective generation of 2-oxo-histidine at the histidine 118. J Biol Chem 269(4):2405–2410. 39. Traoré DAK, et al. (2009) Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein. Nat Chem Biol 5(1):53–59. 40. Lee J-W, Helmann JD (2006) The PerR transcription factor senses H2O2 by metalcatalysed histidine oxidation. Nature 440(7082):363–367. 41. Goodrich LE, Paulat F, Praneeth VKK, Lehnert N (2010) Electronic structure of hemenitrosyls and its significance for nitric oxide reactivity, sensing, transport, and toxicity in biological systems. Inorg Chem 49(14):6293–6316. 42. He C, Neya S, Knipp M (2011) Breaking the proximal Fe(II)-N(His) bond in heme proteins through local structural tension: Lessons from the heme b proteins nitrophorin 4, nitrophorin 7, and related site-directed mutant proteins. Biochemistry 50(40):8559–8575. 43. Ristow M, Zarse K (2010) How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 45(6):410–418. 44. Decker BL, Wickner WT (2006) Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast. J Biol Chem 281(20):14523–14528. 45. Charizanis C, Juhnke H, Krems B, Entian KD (1999) The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7). Mol Gen Genet 262(3):437–447. 46. Martins D, English AM (2014) Catalase activity is stimulated by H(2)O(2) in rich culture medium and is required for H(2)O(2) resistance and adaptation in yeast. Redox Biol 2: 308–313. 47. Lee J, et al. (1999) Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem 274(23):16040–16046. 48. Toledano MB, Delaunay A, Monceau L, Tacnet F (2004) Microbial H2O2 sensors as archetypical redox signaling modules. Trends Biochem Sci 29(7):351–357. 49. Kiley PJ, Storz G (2004) Exploiting thiol modifications. PLoS Biol 2(11):e400. 50. Erman JE, Vitello LB (2002) Yeast cytochrome c peroxidase: Mechanistic studies via protein engineering. Biochim Biophys Acta 1597(2):193–220. 51. Chen S, Brockenbrough JS, Dove JE, Aris JP (1997) Homocitrate synthase is located in the nucleus in the yeast Saccharomyces cerevisiae. J Biol Chem 272(16):10839–10846.