Healthcare workers, especially nurses, are susceptible to burnout at more prevalent rates than the rest of the population. We argue that one way to mitigate rates of burnout in healthcare is by putting a spotlight on the Strengths-Based Nursing and Healthcare Leadership (SBNH-L) approach. Literature on SBNH-L is in its infancy, and no literature to date has looked at this leadership approach in relation to burnout. This study aimed to understand how SBNH-L can foster a culture of inclusion in nursing (and healthcare) and how this can be reflected in the rates of burnout among nurses and other healthcare employees. We surveyed 357 healthcare workers in Canada (144 of whom were nurses) using the AskingCanadians online data collection service. The participants were asked to complete the SBNH-L questionnaire in relation to their manager, a perceived inclusion questionnaire and a self-rated burnout questionnaire. To analyze the data, we conducted a mediation analysis using the PROCESS macro on SPSS. The results showed that inclusion partially mediated the relationship between SBNH-L and emotional exhaustion in the full healthcare sample. These results contribute to findings on the newly developed leadership approach of SBNH-L. They also extend into the clinical world to provide insight into inclusion as a mechanism to mitigate burnout rates.