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The effects of a multisite aerobic exercise intervention on asthma morbidity in sedentary adults with asthma: the Ex-asthma study randomised controlled trial protocol

Title:

The effects of a multisite aerobic exercise intervention on asthma morbidity in sedentary adults with asthma: the Ex-asthma study randomised controlled trial protocol

Bacon, Simon L., Lavoie, Kim L., Bourbeau, Jean, Ernst, Pierre, Maghni, Karim, Gautrin, Denyse, Labrecque, Manon, Pepin, Véronique and Pedersen, Bente K. (2013) The effects of a multisite aerobic exercise intervention on asthma morbidity in sedentary adults with asthma: the Ex-asthma study randomised controlled trial protocol. BMJ Open, 3 (6). e003177-e003177. ISSN 2044-6055

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Official URL: http://dx.doi.org/10.1136/bmjopen-2013-003177

Abstract

Objective: Aerobic exercise can improve cardiovascular fitness and does not seem to be detrimental to patients with asthma, though its role in changing asthma control and inflammatory profiles is unclear. The main hypothesis of the current randomised controlled trial is that aerobic exercise will be superior to usual care in improving asthma control. Key secondary outcomes are asthma quality of life and inflammatory profiles.

Design: A total of 104 sedentary adults with physician-diagnosed asthma will be recruited. Eligible participants will undergo a series of baseline assessments including: the asthma control questionnaire; the asthma quality-of-life questionnaire and the inflammatory profile (assessed from both the blood and sputum samples). On completion of the assessments, participants will be randomised (1:1 allocation) to either 12-weeks of usual care or usual care plus aerobic exercise. Aerobic exercise will consist of three supervised training sessions per week. Each session will consist of taking a short-acting bronchodilator, 10 min of warm-up, 40 min of aerobic exercise (50–75% of heart rate reserve for weeks 1–4, then 70–85% for weeks 5–12) and a 10 min cool-down. Within 1 week of completion, participants will be reassessed (same battery as at baseline). Analyses will assess the difference between the two intervention arms on postintervention levels of asthma control, quality of life and inflammation, adjusting for age, baseline inhaled corticosteroid prescription, body weight change and pretreatment dependent variable level. Missing data will be handled using standard multiple imputation techniques.

Ethics and dissemination: The study has been approved by all relevant research ethics boards. Written consent will be obtained from all participants who will be able to withdraw at any time.

Results: The result will be disseminated to three groups of stakeholder groups: (1) the scientific and professional community; (2) the research participants and (3) the general public.

Registration Details: ClinicalTrials.gov Identifier NCT00953342

Divisions:Concordia University > Faculty of Arts and Science > Exercise Science
Item Type:Article
Refereed:Yes
Authors:Bacon, Simon L. and Lavoie, Kim L. and Bourbeau, Jean and Ernst, Pierre and Maghni, Karim and Gautrin, Denyse and Labrecque, Manon and Pepin, Véronique and Pedersen, Bente K.
Journal or Publication:BMJ Open
Date:19 June 2013
Funders:
  • Concordia Open Access Author Fund
Digital Object Identifier (DOI):10.1136/bmjopen-2013-003177
ID Code:978058
Deposited By: DAVID MACAULAY
Deposited On:10 Dec 2013 16:28
Last Modified:18 Jan 2018 17:45
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