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Thiol-responsive block copolymer nanocarriers exhibiting tunable release with morphology changes

Title:

Thiol-responsive block copolymer nanocarriers exhibiting tunable release with morphology changes

Zhang, Qian, Aleksanian, Samuel, Noh, Seung Man and Oh, Jung Kwon (2013) Thiol-responsive block copolymer nanocarriers exhibiting tunable release with morphology changes. Polymer Chemistry, 4 (2). p. 351. ISSN 1759-9954

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Official URL: http://dx.doi.org/10.1039/C2PY20582C

Abstract

New thiol-responsive nanocarriers of amphiphilic block copolymers consisting of a pendent disulfide-labeled methacrylate polymer block (PHMssEt) and a hydrophilic poly(ethylene oxide) (PEO) block were reported. These well-controlled block copolymers were synthesized by atom transfer radical polymerization (ATRP) of a new pendent disulfide-functionalized methacrylate (HMssEt) in the presence of PEO-Br macroinitiator. Due to its amphiphilic nature, the PEO-b-PHMssEt with narrow molecular weight distribution self-assembled in aqueous solution to form monomodal micellar aggregates with PHMssEt cores surrounded with hydrophilic PEO coronas. In response to thiols, the disulfide linkages were cleaved, and thus self-assembled micelles were either converted to core-crosslinked micelles or destabilized to further disintegrate, depending on the amount of added thiols. Such change in morphology led to tunable release of encapsulated model drugs in aqueous solutions.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Article
Refereed:Yes
Authors:Zhang, Qian and Aleksanian, Samuel and Noh, Seung Man and Oh, Jung Kwon
Journal or Publication:Polymer Chemistry
Date:2013
Digital Object Identifier (DOI):10.1039/C2PY20582C
ID Code:978147
Deposited By: DAVID MACAULAY
Deposited On:10 Jan 2014 19:30
Last Modified:18 Jan 2018 17:46
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