Login | Register

Altered regional cerebral blood flow in idiopathic hypersomnia

Title:

Altered regional cerebral blood flow in idiopathic hypersomnia

Boucetta, Soufiane, Montplaisir, Jacques, Zadra, Antonio, Lachapelle, Francis, Soucy, Jean-Paul, Gravel, Paul and Dang-Vu, Thien Thanh (2017) Altered regional cerebral blood flow in idiopathic hypersomnia. Sleep . ISSN 0161-8105 (In Press)

[img]
Preview
Text (application/pdf)
boucetta_sleep_2017_inpress.pdf - Accepted Version
Available under License Spectrum Terms of Access.
901kB

Official URL: http://dx.doi.org/10.1093/sleep/zsx140

Abstract

Objectives
Idiopathic hypersomnia is characterized by excessive daytime sleepiness despite normal or long sleep time. Its pathophysiological mechanisms remain unclear. This pilot study aims at characterizing the neural correlates of idiopathic hypersomnia using single photon emission computed tomography.
Methods
Thirteen participants with idiopathic hypersomnia and sixteen healthy controls were scanned during resting wakefulness using a high-resolution single photon emission computed tomography scanner with 99mTc-ethyl cysteinate dimer to assess cerebral blood flow. The main analysis compared regional cerebral blood flow distribution between the two groups. Exploratory correlations between regional cerebral blood flow and clinical characteristics evaluated the functional correlates of those brain perfusion patterns. Significance was set at p <0.05 after correction for multiple comparisons.
Results
Idiopathic hypersomnia participants showed regional cerebral blood flow decreases in medial prefrontal cortex, posterior cingulate cortex and putamen, as well as increases in amygdala and temporo-occipital cortices. Lower regional cerebral blood flow in the medial prefrontal cortex was associated with higher daytime sleepiness.
Conclusions
These preliminary findings suggest that idiopathic hypersomnia is characterized by functional alterations in brain areas involved in the modulation of vigilance states, which may contribute to the daytime symptoms of this condition. The distribution of regional cerebral blood flow changes was reminiscent of the patterns associated with normal non-rapid-eye-movement sleep, suggesting the possible presence of incomplete sleep-wake transitions. These abnormalities were strikingly distinct from those induced by acute sleep deprivation, suggesting that the patterns seen here might reflect a trait associated with idiopathic hypersomnia rather than a non-specific state of sleepiness.

Divisions:Concordia University > Faculty of Arts and Science > Exercise Science
Item Type:Article
Refereed:Yes
Authors:Boucetta, Soufiane and Montplaisir, Jacques and Zadra, Antonio and Lachapelle, Francis and Soucy, Jean-Paul and Gravel, Paul and Dang-Vu, Thien Thanh
Journal or Publication:Sleep
Date:23 August 2017
Funders:
  • Sleep Research Society Foundation
  • Canadian Institutes of Health Research (CIHR)
  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Fonds de Recherche du Québec – Santé (FRQ-S)
  • Canada Foundation for Innovation (CFI)
  • American Sleep Medicine Foundation
  • Institut Universitaire de Gériatrie de Montréal
Digital Object Identifier (DOI):10.1093/sleep/zsx140
Keywords:idiopathic hypersomnia, single photon emission computed tomography, sleepiness, sleep disorders
ID Code:983027
Deposited By: DANIELLE DENNIE
Deposited On:13 Sep 2017 20:25
Last Modified:01 Aug 2018 00:00

References:

1. Billiard M, Sonka K. Idiopathic hypersomnia. Sleep medicine reviews. Oct 2016;29:23-33.

2. Vernet C, Arnulf I. Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients. Sleep. Jun 2009;32(6):753-759.

3. Ohayon MM. From wakefulness to excessive sleepiness: what we know and still need to know. Sleep medicine reviews. Apr 2008;12(2):129-141.

4. Dauvilliers Y, Paquereau J, Bastuji H, Drouot X, Weil JS, Viot-Blanc V. Psychological health in central hypersomnias: the French Harmony study. Journal of neurology, neurosurgery, and psychiatry. Jun 2009;80(6):636-641.

5. Montplaisir J, Fantini L. Idiopathic hypersomnia: a diagnostic dilemma. A commentary of "Idiopathic hypersomnia" (M. Billiard and Y. Dauvilliers). Sleep medicine reviews. Oct 2001;5(5):361-362.

6. Trotti LM, Saini P, Bliwise DL, Freeman AA, Jenkins A, Rye DB. Clarithromycin in gammaaminobutyric acid-Related hypersomnolence: A randomized, crossover trial. Annals of neurology. Sep 2015;78(3):454-465.

7. Trotti LM, Saini P, Freeman AA, et al. Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience. Journal of psychopharmacology. Jul 2014;28(7):697-702.

8. Rye DB, Bliwise DL, Parker K, et al. Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Science translational medicine. Nov 21 2012;4(161):161ra151.

9. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. Jan 1 2000;355(9197):39-40.

10. Heier MS, Evsiukova T, Vilming S, Gjerstad MD, Schrader H, Gautvik K. CSF hypocretin-1 levels and clinical profiles in narcolepsy and idiopathic CNS hypersomnia in Norway. Sleep. Aug 2007;30(8):969-973.

11. Dauvilliers Y, Comte F, Bayard S, Carlander B, Zanca M, Touchon J. A brain PET study in patients with narcolepsy-cataplexy. Journal of neurology, neurosurgery, and psychiatry. Mar 2010;81(3):344-348.

12. Joo EY, Hong SB, Tae WS, et al. Cerebral perfusion abnormality in narcolepsy with cataplexy. NeuroImage. Nov 1 2005;28(2):410-416.

13. Joo EY, Tae WS, Kim JH, Kim BT, Hong SB. Glucose hypometabolism of hypothalamus and thalamus in narcolepsy. Annals of neurology. Sep 2004;56(3):437-440.

14. Buskova J, Vaneckova M, Sonka K, Seidl Z, Nevsimalova S. Reduced hypothalamic gray matter in narcolepsy with cataplexy. Neuro endocrinology letters. Dec 2006;27(6):769-772.

15. Draganski B, Geisler P, Hajak G, et al. Hypothalamic gray matter changes in narcoleptic patients. Nature medicine. Nov 2002;8(11):1186-1188.

16. Scherfler C, Frauscher B, Schocke M, et al. White and gray matter abnormalities in narcolepsy with cataplexy. Sleep. Mar 2012;35(3):345-351.

17. Drissi NM, Szakacs A, Witt ST, et al. Altered Brain Microstate Dynamics in Adolescents with Narcolepsy. Frontiers in human neuroscience. 2016;10:369.

18. O'Byrne J, Salimi A, Dang-Vu TT. Neuroimaging of Narcolepsy. Goswami M, Thorpy MJ, eds. Narcolepsy, 2nd Edition: A Clinical Guide: Springer; 2016.

19. Park YK, Kwon OH, Joo EY, et al. White matter alterations in narcolepsy patients with cataplexy: tract-based spatial statistics. Journal of sleep research. Apr 2016;25(2):181-189.

20. AASM. International classification of sleep disorders, 3rd ed. In: Medicine AAoS, ed. Diagnostic and coding manual. Westchester, IL2014.

21. American Psychiatric Association. Diagnostic and statistical manual of mental disorders : DSM-5. 5th ed. Washington, D.C.: American Psychiatric Association; 2013.

22. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. Dec 1991;14(6):540-545.

23. Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry research. May
1989;28(2):193-213.

24. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Archives of general psychiatry. Jun 1961;4:561-571.

25. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. Journal of consulting and clinical psychology. Dec 1988;56(6):893-897.

26. Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. International journal of chronobiology. 1976;4(2):97-110.

27. Dang-Vu TT, Desseilles M, Laureys S, et al. Cerebral correlates of delta waves during non-REM sleep revisited. NeuroImage. Oct 15 2005;28(1):14-21.

28. Horovitz SG, Braun AR, Carr WS, et al. Decoupling of the brain's default mode network during deep sleep. Proceedings of the National Academy of Sciences of the United States of America. Jul 7 2009;106(27):11376-11381.

29. Kim MJ, Gee DG, Loucks RA, Davis FC, Whalen PJ. Anxiety dissociates dorsal and ventral medial prefrontal cortex functional connectivity with the amygdala at rest. Cerebral cortex. Jul 2011;21(7):1667-1673.

30. Kim YH, Gitelman DR, Nobre AC, Parrish TB, LaBar KS, Mesulam MM. The large-scale neural network for spatial attention displays multifunctional overlap but differential asymmetry. NeuroImage. Mar 1999;9(3):269-277.

31. Maquet P, Degueldre C, Delfiore G, et al. Functional neuroanatomy of human slow wave sleep. The Journal of neuroscience : the official journal of the Society for Neuroscience. Apr 15 1997;17(8):2807-2812.

32. Reinsel RA, Veselis RA, Dnistrian AM, Feshchenko VA, Beattie BJ, Duff MR. Midazolam decreases cerebral blood flow in the left prefrontal cortex in a dose-dependent fashion. The international journal of neuropsychopharmacology. Jun 2000;3(2):117-127.

33. Ward AM, McLaren DG, Schultz AP, et al. Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects. Sleep. Nov 2013;36(11):1609-1615.

34. Ad-Dab'bagh Y, Einarson D, Lyttelton O, et al. The CIVET image-processing environment: A fully automated comprehensive pipeline for anatomical neuroimaging research. Paper presented at: Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping2006; Florence, Italy,.

35. Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE transactions on medical imaging. Feb 1998;17(1):87-97.

36. Collins DL, Neelin P, Peters TM, Evans AC. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. Journal of computer assisted tomography. MarApr 1994;18(2):192-205.

37. Mazziotta J, Toga A, Evans A, et al. A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philosophical transactions of the Royal Society of London. Series B, Biological sciences. Aug 29 2001;356(1412):1293-1322.

38. Fonov V, Evans AC, McKinstry RC, Almli CR, Collins DL. Unbiased nonlinear average ageappropriate brain templates from birt to adulthood. NeuroImage. 2009;47(Supplement 1):S102.

39. Nakamura M, Nishida S, Hayashida K, Ueki Y, Dauvilliers Y, Inoue Y. Differences in brain morphological findings between narcolepsy with and without cataplexy. PloS one. 2013;8(11):e81059

40. Gusnard DA, Raichle ME, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nature reviews. Neuroscience. Oct 2001;2(10):685-694.
41. Morecraft RJ, Geula C, Mesulam MM. Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey. The Journal of comparative neurology. Sep 15 1992;323(3):341-358.

42. Baxter LR, Jr., Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Archives of general psychiatry. Mar 1987;44(3):211-218.

43. Rauch SL, Shin LM. Functional neuroimaging studies in posttraumatic stress disorder. Annals of the New York Academy of Sciences. Jun 21 1997;821:83-98.

44. Killgore WD, Schwab ZJ, Kipman M, DelDonno SR, Weber M. Voxel-based morphometric gray matter correlates of daytime sleepiness. Neuroscience letters. Jun 14 2012;518(1):10-13.

45. Northoff G, Walter M, Schulte RF, et al. GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature neuroscience. Dec 2007;10(12):1515-1517.

46. Veselis RA, Reinsel RA, Beattie BJ, et al. Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography study. Anesthesiology. Nov 1997;87(5):1106-1117.

47. Abercrombie HC, Schaefer SM, Larson CL, et al. Metabolic rate in the right amygdala predicts negative affect in depressed patients. Neuroreport. Oct 5 1998;9(14):3301-3307.

48. Drevets WC, Price JL, Bardgett ME, Reich T, Todd RD, Raichle ME. Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacology, biochemistry, and behavior. Mar 2002;71(3):431-47.

49. Nofzinger EA, Buysse DJ, Miewald JM, et al. Human regional cerebral glucose metabolism during non-rapid eye movement sleep in relation to waking. Brain : a journal of neurology. May 2002;125(Pt 5):1105-1115.

50. Schwartz S, Ponz A, Poryazova R, et al. Abnormal activity in hypothalamus and amygdala during humour processing in human narcolepsy with cataplexy. Brain : a journal of neurology. Feb 2008;131(Pt 2):514-522.

51. Dang-Vu TT, Zadra A, Labelle MA, Petit D, Soucy JP, Montplaisir J. Sleep Deprivation Reveals Altered Brain Perfusion Patterns in Somnambulism. PloS one. 2015;10(8):e0133474.

52. Braun AR, Balkin TJ, Wesenten NJ, et al. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain : a journal of neurology. Jul 1997;120 ( Pt 7):1173-1197.
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Downloads per month over past year

Research related to the current document (at the CORE website)
- Research related to the current document (at the CORE website)
Back to top Back to top