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Modeling Renal Disease “On the Fly”

Title:

Modeling Renal Disease “On the Fly”

Millet-Boureima, Cassandra, Porras Marroquin, Jessica and Gamberi, Chiara (2018) Modeling Renal Disease “On the Fly”. BioMed Research International, 2018 . pp. 1-13. ISSN 2314-6133

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Official URL: http://dx.doi.org/10.1155/2018/5697436

Abstract

Detoxification is a fundamental function for all living organisms that need to excrete catabolites and toxins to maintain homeostasis. Kidneys are major organs of detoxification that maintain water and electrolyte balance to preserve physiological functions of vertebrates. In insects, the renal function is carried out by Malpighian tubules and nephrocytes. Due to differences in their circulation, the renal systems of mammalians and insects differ in their functional modalities, yet carry out similar biochemical and physiological functions and share extensive genetic and molecular similarities. Evolutionary conservation can be leveraged to model specific aspects of the complex mammalian kidney function in the genetic powerhouse Drosophila melanogaster to study how genes interact in diseased states. Here, we compare the human and Drosophila renal systems and present selected fly disease models.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Refereed:Yes
Authors:Millet-Boureima, Cassandra and Porras Marroquin, Jessica and Gamberi, Chiara
Journal or Publication:BioMed Research International
Date:2018
Funders:
  • Concordia Open Access Author Fund
  • CUPFA Professional Development Award
Digital Object Identifier (DOI):10.1155/2018/5697436
ID Code:983929
Deposited By: DANIELLE DENNIE
Deposited On:04 Jun 2018 13:34
Last Modified:04 Jun 2018 13:34

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