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Challenges Related to Three Cases of Fatal Intoxication to Multiple Novel Synthetic Opioids

Title:

Challenges Related to Three Cases of Fatal Intoxication to Multiple Novel Synthetic Opioids

Garneau, Béatrice, Desharnais, Brigitte ORCID: https://orcid.org/0000-0001-7373-656X, Beauchamp-Doré, Audrey, Lavallée, Catherine, Mireault, Pascal and Lajeunesse, André (2019) Challenges Related to Three Cases of Fatal Intoxication to Multiple Novel Synthetic Opioids. Journal of Analytical Toxicology . ISSN 0146-4760

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Official URL: https://doi.org/10.1093/jat/bkz018

Abstract

In the last two decades, a large increase in opioid overdose death rates has been recorded in North America. This phenomenon, related to the misuse of prescription opioids, has been dubbed an “opioids crisis”. Recent years have seen the entrance of novel synthetic opioids (NSO) on the market, compounding the fatal intoxications issue. This brings several challenges for forensic toxicology laboratories: an increased number of cases, a large number of novel structurally similar compounds to include in screening analytical methods, the low concentration of drugs in biological fluids, and the challenging interpretation in the absence of sufficient literature. Three cases of fatal intoxication highlighting those challenges are presented, complete with post-mortem concentrations in cardiac blood, femoral blood and urine. Toxicological screening and quantitative analyses were performed on the biological specimens. In the first and second cases, furanylfentanyl, U-47700 and 4-anilino-N-phenethylpiperidine (4-ANPP) were detected at similar concentrations in cardiac blood. In the third case, a total of seventeen different NSO were detected. All intoxications showed a combination of NSO and other drugs. These three cases appear to be the harbinger of an increased NSO prevalence in the province of Québec, Canada.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Article
Refereed:Yes
Authors:Garneau, Béatrice and Desharnais, Brigitte and Beauchamp-Doré, Audrey and Lavallée, Catherine and Mireault, Pascal and Lajeunesse, André
Journal or Publication:Journal of Analytical Toxicology
Date:30 March 2019
Digital Object Identifier (DOI):10.1093/jat/bkz018
Keywords:new psychoactive substances, novel synthetic opioids, intoxication, U-47700, furanylfentanyl
ID Code:986214
Deposited By: BRIGITTE DESHARNAIS
Deposited On:15 Jan 2020 20:36
Last Modified:30 Mar 2020 00:00
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References:

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