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Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Title:

Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Millet-Boureima, Cassandra ORCID: https://orcid.org/0000-0002-1521-0778, Polyak, Felix, Rozencwaig, Roman and Gamberi, Chiara ORCID: https://orcid.org/0000-0002-7122-6491 (2020) Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease. Molecules, 25 . ISSN 1420-3049

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Official URL: https://doi.org/10.3390/molecules25225477

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Refereed:Yes
Authors:Millet-Boureima, Cassandra and Polyak, Felix and Rozencwaig, Roman and Gamberi, Chiara
Journal or Publication:Molecules
Date:23 November 2020
Funders:
  • Mitacs Accelerate Grant IT10214
  • Concordia University CUPFA Professional Development Grant to C.G.
Digital Object Identifier (DOI):10.3390/molecules25225477
ID Code:987898
Deposited By: CHIARA GAMBERI
Deposited On:10 Feb 2021 20:27
Last Modified:10 Feb 2021 20:27
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