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Peroxisomal Membrane Fusion Requires Two Aaa Family Atpases, Pex1p and Pex6p


Peroxisomal Membrane Fusion Requires Two Aaa Family Atpases, Pex1p and Pex6p

Titorenko, Vladimir I. ORCID: https://orcid.org/0000-0001-5819-7545 and Rachubinski, Richard A. (2000) Peroxisomal Membrane Fusion Requires Two Aaa Family Atpases, Pex1p and Pex6p. The Journal of Cell Biology, 150 (4). pp. 881-886. ISSN 0021-9525

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Official URL: http://dx.doi.org/10.1083/jcb.150.4.881


Two AAA family ATPases, NSF and p97, have been implicated in membrane fusion during assembly and inheritance of organelles of the secretory pathway. We have now investigated the roles of AAA ATPases in membrane fusion during assembly of the peroxisome, an organelle outside the classical secretory system. Here, we show that peroxisomal membrane fusion in the yeast Yarrowia lipolytica requires two AAA ATPases, Pex1p and Pex6p. Release of membrane- associated Pex1p and Pex6p drives the asymmetric priming of two fusion partners. The next step, peroxisome docking, requires release of Pex1p from one partner. Subsequent fusion of the peroxisomal membranes is independent of both Pex1p and Pex6p.

Divisions:Concordia University > Faculty of Arts and Science > Biology
Item Type:Article
Authors:Titorenko, Vladimir I. and Rachubinski, Richard A.
Journal or Publication:The Journal of Cell Biology
Date:21 August 2000
Digital Object Identifier (DOI):10.1083/jcb.150.4.881
ID Code:7570
Deposited By: Danielle Dennie
Deposited On:11 May 2011 17:06
Last Modified:28 May 2019 19:03


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