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17β-estradiol locally increases phasic dopamine release in the dorsal striatum


17β-estradiol locally increases phasic dopamine release in the dorsal striatum

Shams, Waqqas M., Cossette, Marie-Pierre, Shizgal, Peter ORCID: https://orcid.org/0000-0003-4265-0792 and Brake, Wayne G. (2017) 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Neuroscience Letters . ISSN 0304-3940 (In Press)

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Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anaesthetized (1.5 mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of ∼ 20–25 pg/ml. DA release was evoked every 1 min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8 pg/μl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Authors:Shams, Waqqas M. and Cossette, Marie-Pierre and Shizgal, Peter and Brake, Wayne G.
Journal or Publication:Neuroscience Letters
Date:22 November 2017
  • Natural Sciences and Engineering Research Council (NSERC) of Canada [WGB: RGPIN-2016-06653; PS, RGPIN-308-11]
Digital Object Identifier (DOI):10.1016/j.neulet.2017.11.039
Keywords:Estrogens; fast-scan cyclic voltammetry
ID Code:983224
Deposited By: Danielle Dennie
Deposited On:22 Nov 2017 19:38
Last Modified:20 Nov 2018 01:00


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