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Cerebello-Cortical Coherence of Local Field Potentials following Patterned Stimulation of the Cerebellar Vermis


Cerebello-Cortical Coherence of Local Field Potentials following Patterned Stimulation of the Cerebellar Vermis

Tremblay, Stéfanie (2018) Cerebello-Cortical Coherence of Local Field Potentials following Patterned Stimulation of the Cerebellar Vermis. Masters thesis, Concordia University.

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The cerebellum is involved in sensorimotor, cognitive, and emotional functions through cerebello- cerebral connectivity. Non-invasive cerebellar neurostimulation has been used to treat neurological disorders and has positive effects on cognition and mood, which have been related to modulation in frontal oscillations. To explore the mechanisms, we studied the effects of cerebellar stimulation at various frequencies on oscillations and coherence across a cerebello-cortical network, in the anesthetized rat. Local field potentials were recorded continuously with monopolar and bipolar electrodes in the lateral cerebellum (crus I/II), and in the prefrontal cortex (FrA), in six adult male Sprague-Dawley rats anesthetized with urethane. Stimulation patterns were delivered to the cerebellar vermis (lobule VII) in a randomized order: single pulses (0.2 Hz for 60 s), and repeated pulses at 1 Hz (30 s), 5 Hz (10 s), 25 Hz (2 s), and 50 Hz (1 s). Low frequency stimulation (1 Hz and 5 Hz) enhanced coherence in the cerebello-cortical network in theta and alpha, while high frequency stimulation (50 Hz) had an enhancing effect on beta and low gamma coherence. Stimulation effects were influenced by the initial oscillatory state, perhaps due to cyclic stages under urethane anesthesia. Low frequency stimulation was more efficient when delivered in a state dominated by slow waves, while high frequency stimulation showed the opposite relationship. We have found here that cerebellar stimulation can drive synchronization of cerebello-cortical and cortico-cortical networks. The present results could provide basic mechanisms underlying the therapeutic effects of cerebellar stimulation by promoting large-scale synchronization of neural networks.

Divisions:Concordia University > Faculty of Arts and Science > Health, Kinesiology and Applied Physiology
Item Type:Thesis (Masters)
Authors:Tremblay, Stéfanie
Institution:Concordia University
Degree Name:M. Sc.
Program:Exercise Science
Date:10 December 2018
Thesis Supervisor(s):Courtemanche, Richard
Keywords:oscillations, synchrony, cerebellum, vermis, prefrontal cortex
ID Code:984871
Deposited On:03 Feb 2021 19:55
Last Modified:03 Feb 2021 19:55


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