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Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length


Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length

Huang, Yi, Onn Siong, Yim, San Lai, Poh, Yu, Rongjun, Hong Chew, Soo, Gwee, Xinyi, Shwe Zin Nyunt, Ma, Gao, Qi, Ng, Tze Pin, Ebstein, Richard P. and Gouin, Jean-Philippe (2019) Successful aging, cognitive function, socioeconomic status, and leukocyte telomere length. Psychoneuroendocrinology . ISSN 03064530 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.psyneuen.2019.01.015


In a rapidly greying world, the notion that some individuals maintain successful aging trajectories, viz. high physical, cognitive, emotional, and social functioning in older age, is increasingly germane. Biomarkers of such successful aging are increasingly sought. Leukocyte telomere length (LTL), an emerging yardstick of cellular aging that is influenced by but distinct from chronological age, may also be associated to successful aging. Furthermore, given that socio-economic status (SES) influences successful aging trajectories, socioeconomic status may also moderate the association between chronological age and LTL. The goals of this study are to examine 1) whether successful aging is associated with LTL; 2) whether successful aging accounts for age-related LTL and 3) whether low SES moderates the effect of age on LTL. Singaporean Chinese (n = 353) aged 65-80 completed a multidimensional assessment of successful aging and provided blood samples for LTL analysis. Results show that LTL negatively correlates with chronological age and positively correlates with successful aging. Successful aging mediates the association between chronological age and LTL. Moderated mediation analyses show that lower SES is associated with stronger negative associations of chronological age with successful aging and LTL. Moreover, the cognitive functioning dimension of successful aging is uniquely associated with LTL and its association with chronological age is moderated by SES. This study provides evidence that among older Singaporean Chinese with lower SES, declines in successful aging and in cognitive functioning are linked to age-related LTL shortening and hence to accelerated aging at the cellular level.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Authors:Huang, Yi and Onn Siong, Yim and San Lai, Poh and Yu, Rongjun and Hong Chew, Soo and Gwee, Xinyi and Shwe Zin Nyunt, Ma and Gao, Qi and Ng, Tze Pin and Ebstein, Richard P. and Gouin, Jean-Philippe
Journal or Publication:Psychoneuroendocrinology
Date:17 January 2019
  • Singapore Ministry of Education’s Academic Research Fund Tier 2 grant MOE2013-T2-1-048
  • Biomedical Research Council (Grant BMRC/08/1/21/19/567)
  • National Medical Research Council (NMRC/CIRG/1409/2014)
  • Canada Research Chair Secretariat
Digital Object Identifier (DOI):10.1016/j.psyneuen.2019.01.015
ID Code:984959
Deposited By: Monique Lane
Deposited On:31 Jan 2019 16:55
Last Modified:17 Jan 2020 01:00


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