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The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery


The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery

Khoo, Shaun Yon-Seng ORCID: https://orcid.org/0000-0002-0972-3788, Sciascia, Joanna Marie, Pettorelli, Annie, Maddux, Jean-Marie and Chaudhri, Nadia ORCID: https://orcid.org/0000-0003-4217-4044 (2019) The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery. Journal of Psychopharmacology . ISSN 02698811

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Official URL: https://doi.org/10.1177/0269881119844180


Background: The prelimbic medial prefrontal cortex is implicated in promoting drug-seeking in relapse tests. However, drug-seeking behaviour is typically extinguished before a test and tests normally occur without drug delivery.
Aims: We investigated the involvement of the prelimbic and the infralimbic cortex in responding elicited by a non-extinguished cue for alcohol that was presented without alcohol in an alcohol-associated context or a neutral context, and in responding to the same cue when it was paired with alcohol.
Methods: Male, Long-Evans rats (220–240 g on arrival) were acclimated to 15% ethanol (v/v; ‘alcohol’) and then trained to associate a conditioned stimulus (10 s white noise; 15 trials/session) with alcohol delivery into a fluid port (0.2 mL/conditioned stimulus, 3 mL per session) for oral intake. Conditioning sessions occurred in a specific ‘alcohol context’ and were alternated daily with exposure to a second ‘neutral’ context that contained neither the conditioned stimulus nor alcohol.
Results: At test, functional prelimbic cortex inactivation using baclofen/muscimol reduced fluid port entries elicited by a non-extinguished conditioned stimulus that was presented without alcohol, but had no subsequent impact on port entries when the conditioned stimulus was paired with alcohol. Similar results were obtained following infralimbic cortex inactivation; however, infralimbic cortex inactivation also non-specifically reduced port entries in the absence of alcohol.
Conclusions: These data indicate that the prelimbic and infralimbic cortex are involved in responding to cues for alcohol

Divisions:Concordia University > Research Units > Centre for Studies in Behavioural Neurobiology
Item Type:Article
Authors:Khoo, Shaun Yon-Seng and Sciascia, Joanna Marie and Pettorelli, Annie and Maddux, Jean-Marie and Chaudhri, Nadia
Journal or Publication:Journal of Psychopharmacology
Date:9 May 2019
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council
  • Fonds de la recherche du Québec-Santé
Digital Object Identifier (DOI):10.1177/0269881119844180
Keywords:Prelimbic cortex, infralimbic cortex, ethanol, Pavlovian conditioning, context, goal-tracking, reinstatement, relapse, reward
ID Code:985400
Deposited On:17 May 2019 19:50
Last Modified:17 May 2019 19:50
Related URLs:
Additional Information:This accepted manuscript version of the article is shared in accordance with the SAGE’s Archiving and Sharing Policy.


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