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Experimental Investigation of the Flow Dynamics in Models of Patient-Specific Aneurysms


Experimental Investigation of the Flow Dynamics in Models of Patient-Specific Aneurysms

Blons, Hugo (2023) Experimental Investigation of the Flow Dynamics in Models of Patient-Specific Aneurysms. Masters thesis, Concordia University.

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This work investigates the complex flow dynamics in patient-specific compliant models of Abdominal Aortic Aneurysms (AAA) using time-resolved Particle Image Velocimetry (PIV). Scans of multiple planes were performed on three different models: a healthy aorta, a 4-cm saccular AAA, and a 7-cm fusiform AAA. We discuss the differences in flow patterns in patient-specific models compared to idealized models from previous work. We note that the curvature of the aorta upstream from the aneurysm, specific placement of the iliac arteries, and the overall symmetry of the aneurysm have important effects on flow structures, such as increasing transient effects, vortex formation, and wall impingement. Viscous energy dissipation rate (VEDr) was also evaluated as it has been previously identified as a potentially good metric to assess the severity of some vascular diseases.
Finally, a modal analysis was performed on the velocity fields using Proper Orthogonal Decomposition (POD). The main modes obtained were inspected to identify the dominant structures, and the distribution of energy between the modes (Shannon entropy), and to create a reduced-order model of the flow. The results show that Shannon entropy was significantly different between the three models, suggesting that it can be a promising clinical parameter to evaluate the severity of AAAs.

Divisions:Concordia University > Gina Cody School of Engineering and Computer Science > Mechanical, Industrial and Aerospace Engineering
Item Type:Thesis (Masters)
Authors:Blons, Hugo
Institution:Concordia University
Degree Name:M.A. Sc.
Program:Mechanical Engineering
Date:23 August 2023
Thesis Supervisor(s):Kadem, Lyes
Keywords:Flow Dynamics Patient-Specific Abdominal Aortic Aneurysm Particle Image Velocimetry In vitro
ID Code:992896
Deposited By: Hugo Blons
Deposited On:17 Nov 2023 14:27
Last Modified:17 Nov 2023 14:27


ADRIAN, Ronald J., WESTERWEEL, Jerry. Particle Image Velocimetry. Cambridge university press, 2011.

ALEXANDER, J. Jeffrey. The pathobiology of aortic aneurysms. Journal of surgical research, 2004, vol. 117, no 1, p. 163-175.

ARZANI, Amirhossein, SHADDEN, Shawn C. Transport and mixing in patient-specific abdominal aortic aneurysms with lagrangian coherent structures. In: Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. p. 9-10.

ASBURY, Charles L., RUBERTI, Jeffrey W., BLUTH, Edward I., et al. Experimental investigation of steady flow in rigid models of abdominal aortic aneurysms. Annals of biomedical engineering, 1995, vol. 23, p. 29-39.

BARKER, Alex J., PIM VAN, Ooij, KRISHNA, Bandi, et al. Viscous energy loss in the presence of abnormal aortic flow, Magnetic Resonance in Medicine, 2014, vol. 72, no. 3, p. 620-628.

BENARD, Nicolas, JARNY, Sebastien, COISNE, Damien. Definition of an experimental blood like fluid for laser measurements in cardiovascular studies. Applied Rheology, 2007, vol. 17, no 4, p. 44251-1-44251-8.

BETTS, Gordon J., DESAIX, Peter, JOHNSON, Eddie, et al. Anatomy and Physiology. Openstax College, 2013, vol 2, ch. 26, p. 1187-12009

BLUESTEIN, Danny, NIU, Lijun, SCHOEPHOERSTER, Richard T., et al. Steady flow in an aneurysm model: correlation between fluid dynamics and blood platelet deposition, 1996, vol. 118, no 3, p.280-287

BLUTH, Edward I., MURPHEY, Steven M., HOLLIER, Larry H., et al. Color flow Doppler in the evaluation of aortic aneurysms. International Angiology: A journal of the International Union of Angiology, 1990, vol. 9, no 1, p. 8-10.

BOPP, Maximilian, BAUER, Andreas., WEGT, Sebastian, et al. A computational and experimental study of physiological pulsatile flow in an aortic aneurysm. In: Proceedings of the 11th International Symposium on Turbulence and Shear Flow Phenomena, Southampton, UK (United Kingdom). 2019.

BREWSTER, David C., CRONENWETT, Jack L., HALLETT JR, John W., et al. Guidelines for the treatment of abdominal aortic aneurysms: report of a subcommittee of the Joint Council of the American Association for Vascular Surgery and Society for Vascular Surgery. Journal of Vascular Surgery, 2003, vol. 37, no 5, p. 1106-1117.

BRIET, Marie, BOUTOUYRIE, Pierre, LAURENT, Stéphane, et al. Arterial stiffness and pulse pressure in CKD and ESRD. Kidney International, 2012, vol. 82, no 4, p. 388-400.

BRINDISE, Melissa C., BUSSE, Margaret M., VLACHOS, Pavlos P. Density-and viscosity-matched Newtonian and non-Newtonian blood-analog solutions with PDMS refractive index. Experiments in Fluids, 2018, vol. 59, p. 1-8.

BROWNRIGG, Jack R. W., DE BRUIN, Jorg L., ROSSI, Luca, et al. Endovascular aneurysm sealing for infrarenal abdominal aortic aneurysms: 30-day outcomes of 105 patients in a single centre. European Journal of Vascular and Endovascular Surgery, 2015, vol. 50, no 2, p. 157-164.

CANADIAN NUCLEAR SAFETY COMMISSION, 30 March 2023, available from: http://nuclearsafety.gc.ca/eng/resources/radiation/introduction-to-radiation/radiation-doses.cfm

CAZEMIER, Willem. Proper Orthogonal Decomposition and Low Dimensional Models for Turbulent Flows. Rijksuniversiteit Groningen, 1997, ch. 2.

CHEN, Chia-Yuan, ANTÓN, Raúl, HUNG, Ming-yang, et al. Effects of intraluminal thrombus on patient-specific abdominal aortic aneurysm hemodynamics via stereoscopic particle image velocity and computational fluid dynamics modeling. Journal of Biomechanical Engineering, 2014, vol. 136, no 3, p. 031001.

DARWISH, Ahmed, DI LABBIO, Giuseppe, SALEH, Wael, et al. Proper orthogonal decomposition analysis of the flow downstream of a dysfunctional bileaflet mechanical aortic valve. Cardiovascular Engineering and Technology, 2021, vol. 12, p. 286-299.

DEPLANO, Valérie, GUIVIER-CURIEN, Carine, BERTRAND, Eric. 3D analysis of vortical structures in an abdominal aortic aneurysm by stereoscopic PIV. Experiments in Fluids, 2016, vol. 57, p. 1-11.

DEPLANO, Valérie, KNAPP, Yannick, BAILLY, Lucie, et al. Flow of a blood analogue fluid in a compliant abdominal aortic aneurysm model: Experimental modelling. Journal of Biomechanics, 2014, vol. 47, no 6, p. 1262-1269.

DEPLANO, Valerie, KNAPP, Yannick, BERTRAND, Eric, et al. Flow behaviour in an asymmetric compliant experimental model for abdominal aortic aneurysm. Journal of Biomechanics, 2007, vol. 40, no 11, p. 2406-2413.

DI LABBIO, Giuseppe et KADEM, Lyes. Jet collisions and vortex reversal in the human left ventricle. Journal of Biomechanics, 2018, vol. 78, p. 155-160.

DI LABBIO, Giuseppe. On Left Ventricular Fluid Dynamics Associated With Progressive Chronic Aortic Regurgitation. 2019. Thèse de doctorat. Concordia University.

DUCLAUX, Virginie, GALLAIRE, Francois, CLANET, Christophe. A fluid mechanical view on abdominal aortic aneurysms. Journal of Fluid Mechanics, 2010, vol. 664, p. 5-32.

DYVERFELDT, Petter, HOPE, Michael D., TSENG, Elaine, SALONER, David. Magnetic resonance measurement of turbulent kinetic energy for the estimation of irreversible pressure loss in aortic stenosis, JACC: Cardiovascular Imaging, 2013, vol. 6, no. 1, p.64-71.

ENGELHARD, Stefan, VOORNEVELD, Jason, VOS, Hendrik J., et al. High-frame-rate contrast-enhanced ultrasound particle image velocimetry in the abdominal aorta: First human results. Radiology. 2018. vol. 289, no.1, p. 119-125.

ETEBARI, Ali and VLACHOS, Pavlos P. Improvements on the accuracy of derivative estimation from DPIV velocity measurements. Experiments in Fluids, 2005, vol. 39, p. 1040-1050.

FRASER, Katharine H., MEAGHER, Siobhan, BLAKE, James R., et al. Characterization of an abdominal aortic velocity waveform in patients with abdominal aortic aneurysm. Ultrasound in Medicine & Biology, 2008, vol. 34, no 1, p. 73-80.

GOPALAKRISHNAN, Shyam Sunder. Dynamics and Stability of flow through Abdominal Aortic Aneurysms. 2014. Thèse de doctorat. Université Claude Bernard-Lyon I.

HAGER, Alfred, KAEMMERER, Harald, RAPP-BERNHARDT, Ulrike, et al. Diameters of the thoracic aorta throughout life as measured with helical computed tomography. The Journal of Thoracic and Cardiovascular Surgery, 2002, vol. 123, no 6, p. 1060-1066.

HARVEY, William, et al. Exercitatio anatomica de motu cordis et sanguinis in animalibus. Frankfurt am Main, 1928, vol. 1628, p. 17.

HEALTH CANADA, Ultrasound, 10 October 2019 available from: https://www.canada.ca/en/health-canada/services/health-risks-safety/radiation/medical/ultrasound.html

HOLZAPFEL, Gerhard A., GASSER, Thomas C., OGDEN, Ray W.. A new constitutive framework for arterial wall mechanics and a comparative study of material models. Journal of Elasticity and the Physical Science of Solids, 2000, vol. 61, p. 1-48.

IAIZZO, Paul A. (ed.). Handbook of Cardiac Anatomy, Physiology, and Devices. Springer Science & Business Media, 2010.

INDRAKUSUMA, Reza, JALALZADEH, Hamid, VAN DER LAAN, Maarten, et al. 4D Flow MRI in Patients with Asymptomatic Abdominal Aortic Aneurysms: Reproducibility and Clinical Analysis. European Journal of Vascular and Endovascular Surgery, 2019, vol. 58, no 6, p. e652-e654.

ISSELBACHER, Eric M. Thoracic and abdominal aortic aneurysms. Circulation, 2005, vol. 111, no 6, p. 816-828.

KAEWCHOOTHONG, Natthaporn, ALGABRI, Yousif A., ASSAWALERTSAKUL, Thanin, et al. Computational study of abdominal aortic aneurysms with severely angulated neck based on transient hemodynamics using an idealized model. Applied Sciences, 2022, vol. 12, no 4, p. 2113.

KASSEM, Tamer W. Follow up CT angiography post EVAR: Endoleaks detection, classification and management planning. The Egyptian Journal of Radiology and Nuclear Medicine, 2017, vol. 48, no 3, p. 621-626.

KEMMERLING, Erica MC., PEATTIE, Robert A. Abdominal aortic aneurysm pathomechanics: current understanding and future directions. Molecular, Cellular, and Tissue Engineering of the Vascular System, 2018, p. 157-179.

KENT, K. Craig, ZWOLAK, Robert M., EGOROVA, Natalia N., et al. Analysis of risk factors for abdominal aortic aneurysm in a cohort of more than 3 million individuals. Journal of Vascular Surgery, 2010, vol. 52, no 3, p. 539-548.

KHANAFER, Khalil M., BULL, Joseph L., BERGUER, Ramon. Fluid–structure interaction of turbulent pulsatile flow within a flexible wall axisymmetric aortic aneurysm model. European Journal of Mechanics-B/Fluids, 2009, vol. 28, no 1, p. 88-102.

KHE, Alexander K., CHUPAKHIN, Alexander P., CHEREVKO, Alexander A., et al. Viscous dissipation energy as a risk factor in multiple cerebral aneurysms. Russian Journal of Numerical Analysis and Mathematical Modelling, 2015, vol. 30, no 5, p. 277-287.

KU, David N. Blood flow in arteries. Annual Review of Fluid Mechanics, 1997, vol. 29, no 1, p. 399-434.

KUNG, Ethan O., LES, Andrea S., MEDINA, Francisco, et al. In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions. Journal of Biomechanical Engineering, 2011, vol. 133, no 4.

LAENNEC, René Théophile Hyacinthe et LAENNEC, Mériadec. Traité de l'auscultation médiate, et des maladies des poumons et du coeur. JS Chaudé, 1837.

LES, Andrea S., SHADDEN, Shawn C., FIGUEROA, C. Alberto, et al. Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics. Annals of Biomedical Engineering, 2010 a, vol. 38, p. 1288-1313.

LES, Andrea S., YEUNG, Janice J., SCHULTZ, Geoffrey M., et al. Supraceliac and infrarenal aortic flow in patients with abdominal aortic aneurysms: mean flows, waveforms, and allometric scaling relationships. Cardiovascular Engineering and Technology, 2010 b, vol. 1, p. 39-51.

LYNCH, Richard M. Accuracy of abdominal examination in the diagnosis of non-ruptured abdominal aortic aneurysm. Accident and Emergency Nursing, 2004, vol. 12, no 2, p. 99-107.

MARKL, Michael, FRYDRYCHOWICZ, Alex, KOZERKE, Sebastian, et al. 4D flow MRI. Journal of Magnetic Resonance Imaging, 2012, vol. 36, no 5, p. 1015-1036.

MARRERO, Victor L., TICHY, John A., SAHNI, Onkar, et al. Numerical study of purely viscous non-Newtonian flow in an abdominal aortic aneurysm. Journal of Biomechanical Engineering, 2014, vol. 136, no 10, p. 101001.

MAY, James, WHITE, Geoffrey H., WAUGH, Richard, et al. Comparison of first-and second-generation prostheses for endoluminal repair of abdominal aortic aneurysms: a 6-year study with life table analysis. Journal of Vascular Surgery, 2000, vol. 32, no 1, p. 124-129.

MCGREGOR, Robert, SZCZERBA, Dominik, VON SIEBENTHAL, Martin, et al. Exploring the use of proper orthogonal decomposition for enhancing blood flow images via computational fluid dynamics.: Medical Image Computing and Computer-Assisted Intervention–MICCAI 2008: 11th International Conference, New York, NY, USA, September 6-10, 2008, Proceedings, Part II 11. Springer Berlin Heidelberg, 2008. p. 782-789.

MOORE JR, James E., KU, David N., ZARINS, Christopher K., et al. Pulsatile flow visualization in the abdominal aorta under differing physiologic conditions: implications for increased susceptibility to atherosclerosis. The American Society of Mechanical Engineering, 1992, vol. 114, no. 3, p.391-397.

NOROUZI, Shahrzad. Flow Characteristics in Abdominal Aortic Aneurysms: An In Vitro Study. 2020. Master Thesis. Concordia University.

O’ROURKE, Malachy J., MCCULLOUGH, James P., KELLY, Sinead. An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2012, vol. 226, no 7, p. 548-564.

PARASHAR, Abhinav, SINGH, Rahul, PANIGRAHI, Pradipta K., et al. Chaotic flow in an aortic aneurysm. Journal of Applied Physics, 2013, vol. 113, no 21.

PATEL, Shivam, USMANI, Abdullah Y., MURALIDHAR, Krishnamurthy. Effect of aorto-iliac bifurcation and iliac stenosis on flow dynamics in an abdominal aortic aneurysm. Fluid Dynamics Research, 2017, vol. 49, no 3, p. 035513.

PATRICK, JR, Charles, W. MCINTIRE, Larry V. Shear stress and cyclic strain modulation of gene expression in vascular endothelial cells. Blood Purification, 1995, vol. 13, no 3-4, p. 112-124.

PEATTIE, Robert A., RIEHLE, Tiffany J., BLUTH, Edward I. Pulsatile flow in fusiform models of abdominal aortic aneurysms: flow fields, velocity patterns and flow-induced wall stresses. Journal of Biomechanical. Engineering., 2004, vol. 126, no 4, p. 438-446.

PEDRIZZETTI, Gianni et DOMENICHINI, Federico. Nature optimizes the swirling flow in the human left ventricle. Physical Review Letters, 2005, vol. 95, no 10, p. 108101.

POELMA, Christian, WATTON, Paul N., VENTIKOS, Yiannis. Transitional flow in aneurysms and the computation of haemodynamic parameters. Journal of The Royal Society Interface, 2015, vol. 12, no 105, p. 20141394.

RAFFEL, Markus, WILLERT, Christian E., SCARANO, Fulvio, et al. Particle Image Velocimetry: a Practical Guide. Springer, 2018.

SAAID, Hicham, VOORNEVELD, Jason, SCHINKEL, Christiaan, et al. Tomographic PIV in a model of the left ventricle: 3D flow past biological and mechanical heart valves. Journal of Biomechanics, 2019, vol. 90, p. 40-49.

SAKALIHASAN, Natzi, MICHEL, Jean-Baptiste, KATSARGYRIS, Athanasios, et al. Abdominal aortic aneurysms. Nature Reviews Disease Primers, 2018, vol. 4, no 1, p. 34.

SCARANO, Fulvio RIETHMULLER, Michel L. Advances in iterative multigrid PIV image processing. Experiments in Fluids, 2000, vol. 29, no Suppl 1, p. S051-S060.

SCHARNOWSKI, Sven, GRAYSON, Kristian, DE SILVA, Charitha M., et al. Generalization of the PIV loss-of-correlation formula introduced by Keane and Adrian. Experiments in Fluids, 2017, vol. 58, no 10, p. 150.

SCHERMERHORN, Marc. A 66-year-old man with an abdominal aortic aneurysm: review of screening and treatment. Journal of the American Medical Association, 2009, vol. 302, no 18, p. 2015-2022.

SCOTT, Alan P. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. The Lancet, 2002, vol. 360, no 9345, p. 1531-1539.

SCOTTI, Christine M., SHKOLNIK, Alexander D., MULUK, Satish C., et al. Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness. Biomedical Engineering Online, 2005, vol. 4, p. 1-22.

SHADDEN, Shawn C., TAYLOR, Charles A. Characterization of coherent structures in the cardiovascular system. Annals of Biomedical Engineering, 2008, vol. 36, p. 1152-1162.

SIROVICH, Lawrence. Turbulence and the dynamics of coherent structures. I. Coherent structures. Quarterly of Applied Aathematics, 1987, vol. 45, no 3, p. 561-571.

TAIRA, Kunihiko, BRUNTON, Steven L., DAWSON, Scott TM, et al. Modal analysis of fluid flows: An overview. American Institute of Aeronautics and Astronautics’ Journal, 2017, vol. 55, no 12, p. 4013-4041.

TAYLOR, Charles A., CHENG, Christopher P., ESPINOSA, Leandro A., et al. In vivo quantification of blood flow and wall shear stress in the human abdominal aorta during lower limb exercise. Annals of Biomedical Engineering, 2002, vol. 30, p. 402-408.

VERGARA, Christian, LE VAN, Davide, QUADRIO, Maurizio, et al. Large eddy simulations of blood dynamics in abdominal aortic aneurysms. Medical Engineering & Physics, 2017, vol. 47, p. 38-46.

VITELLO, Dominic J., RIPPER, Richard M., FETTIPLACE, Michael R., et al. Blood density is nearly equal to water density: a validation study of the gravimetric method of measuring intraoperative blood loss. Journal of Veterinary Medicine, 2015, vol. 2015, p.4

VLACHOPOULOS, Charalambos, O'ROURKE, Michael, NICHOLS, Wilmer W. McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. CRC press, 2011.

WESTERWEEL, Jerry, SCARANO, Fulvio. Universal outlier detection for PIV data. Experiments in Fluids, 2005, vol. 39, p. 1096-1100.

WILLE, Sven Øivind. Pulsatile pressure and flow in an arterial aneurysm simulated in a mathematical model. Journal of Biomedical Engineering, 1981, vol. 3, no 2, p. 153-158.

WITHERS, Kathleen, CAROLAN-REES, Grace, DALE, Megan. Pipeline™ embolization device for the treatment of complex intracranial aneurysms: a NICE Medical Technology Guidance. Applied Health Economics and Health Policy, 2013, vol. 11, p. 5-13.

YIP, T. H. et YU, S. C. M. Oscillatory flows in straight tubes with an axisymmetric bulge. Experimental thermal and fluid science, 2002, vol. 26, no 8, p. 947-961.

YOUSIF, Majid Y., HOLDSWORTH, David W., POEPPING, Tamie L. A blood-mimicking fluid for particle image velocimetry with silicone vascular models. Experiments in Fluids, 2011, vol. 50, p. 769-774.

YU, Ming-Ching. Steady and pulsatile flow studies in abdominal aortic aneurysm models using particle image velocimetry. International Journal of Heat and Fluid Flow, 2000, vol. 21, no 1, p. 74-83.

ZHAN, Jie-min, LU, Tian-dong, YANG, Zhi-yun, et al. Influence of the flow field and vortex structure of patient-specific abdominal aortic aneurysm with intraluminal thrombus on the arterial wall. Engineering Applications of Computational Fluid Mechanics, 2022, vol. 16, no 1, p. 2100-2122.
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