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Neurodegeneration and the Circadian Clock

Title:

Neurodegeneration and the Circadian Clock

Hood, Suzanne and Amir, Shimon (2017) Neurodegeneration and the Circadian Clock. Frontiers in Aging Neuroscience, 9 (170). pp. 1-9. ISSN 1663-4365

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Official URL: http://dx.doi.org/10.3389/fnagi.2017.00170

Abstract

Despite varied etiologies and symptoms, several neurodegenerative diseases—specifically, Alzheimer’s (AD), Parkinson’s (PD), and Huntington’s diseases (HDs)—share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical activities (e.g., antioxidant production). Circadian disturbances are among the earliest symptoms of these diseases, and the molecular mechanisms of the circadian system are suspected to play a pivotal, and possibly causal, role in their natural histories. Here, we review the common circadian abnormalities observed in ADs, PDs and HDs, and summarize the evidence that the molecular circadian clockwork directly influences the course of these disease states. On the basis of this research, we explore several circadian-oriented interventions proposed as treatments for these neurological disorders.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Hood, Suzanne and Amir, Shimon
Journal or Publication:Frontiers in Aging Neuroscience
Date:2017
Funders:
  • Concordia Open Access Author Fund
Digital Object Identifier (DOI):10.3389/fnagi.2017.00170
Keywords:circadian rhythms, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, neurodegeneration, sleep, clock genes
ID Code:982578
Deposited By: DANIELLE DENNIE
Deposited On:30 May 2017 12:57
Last Modified:18 Jan 2018 17:55
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