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Motivational modulation of rhythms of the expression of the clock protein, PER2, in the limbic forebrain

Title:

Motivational modulation of rhythms of the expression of the clock protein, PER2, in the limbic forebrain

Amir, Shimon and Stewart, Jane (2009) Motivational modulation of rhythms of the expression of the clock protein, PER2, in the limbic forebrain. Biological Psychiatry, 65 (10). pp. 829-834. ISSN 0006-3223

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Official URL: http://dx.doi.org/doi:10.1016/j.biopsych.2008.12.0...

Abstract

Key molecular components of the mammalian circadian clock are expressed rhythmically in many brain areas and peripheral tissues in mammals. Here we review findings from our work on rhythms of expression of the clock protein Period2 (PER2) in four regions of the limbic forebrain known to be important in the regulation of motivational and emotional states. These regions include the oval nucleus of the bed nucleus of the stria terminalis (BNSTov), the central nucleus of the amygdala (CEA), the basolateral amygdala (BLA), and the dentate gyrus (DG). Daily rhythms in the expression of PER2 in these regions are controlled by the master circadian pacemaker, the suprachiasmatic nucleus (SCN), but, importantly, they are also sensitive to homeostatic perturbations and to hormonal states that directly influence motivated behavior. Thus, circadian information from the SCN and homeostatic signals are integrated in these regions of the limbic forebrain to affect the temporal organization of motivational and emotional processes.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Amir, Shimon and Stewart, Jane
Journal or Publication:Biological Psychiatry
Date:May 2009
ID Code:6593
Deposited By:SHIMON AMIR
Deposited On:26 Apr 2010 17:10
Last Modified:08 Dec 2010 18:33
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