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Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus

Title:

Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus

Waddington Lamont, Elaine and Renteria Diaz, Laura and Barry Shaw, Jane and Stewart, Jane and Amir, Shimon (2005) Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus. Neuroscience, 132 (2). pp. 245-248. ISSN 0306-4522

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Official URL: http://dx.doi.org/doi:10.1016/j.neuroscience.2005....

Abstract

Second only to light, daily restricted feeding schedules can entrain circadian rhythms in mammals [Neurosci Biobehav Rev 4 (1980) 119; J Biol Rhythms 17 (2002) 284]. Contrary to light, however, such feeding schedules have been found not to affect the master circadian clock in the suprachiasmatic nucleus (SCN) [Genes Dev 14 (2000) 2950; Eur J Neurosci 13 (2001) 1190]. Here, we show that in rats that are arrhythmic as a consequence of prolonged housing in constant light, a daily restricted feeding schedule not only restores behavioral rhythmicity, as previously shown [Physiol Behav 53 (1993) 509], but in addition, induces a rhythm of the clock protein, Period2 in the SCN. These findings challenge the idea that the SCN is invulnerable to feeding schedules and call for a reevaluation of the role of the SCN clock in the circadian effects of such schedules.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Waddington Lamont, Elaine and Renteria Diaz, Laura and Barry Shaw, Jane and Stewart, Jane and Amir, Shimon
Journal or Publication:Neuroscience
Date:2005
Funders:
  • CIHR
  • CURC
ID Code:6599
Deposited By:SHIMON AMIR
Deposited On:26 Apr 2010 16:22
Last Modified:08 Dec 2010 18:32
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