Titorenko, Vladimir I. and Rachubinski, Richard A. (2004) The peroxisome: orchestrating important developmental decisions from inside the cell. The Journal of Cell Biology, 164 (5). pp. 641-645. ISSN 0021-9525
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Official URL: http://dx.doi.org/10.1083/jcb.200312081
The peroxisome has long been known for its role in lipid metabolism and hydrogen peroxide detoxification. However, growing evidence supports the view that this organelle can also function both as an intracellular signaling compartment and as an organizing platform that orchestrates certain developmental decisions from inside the cell. This review highlights various strategies that peroxisomes employ to regulate the processes of development, differentiation, and morphogenesis and critically evaluates several molecular mechanisms by which peroxisomes promote these processes.
|Divisions:||Concordia University > Faculty of Arts and Science > Biology|
|Authors:||Titorenko, Vladimir I. and Rachubinski, Richard A.|
|Journal or Publication:||The Journal of Cell Biology|
|Date:||23 February 2004|
|Deposited By:||DANIELLE DENNIE|
|Deposited On:||11 May 2011 12:42|
|Last Modified:||11 May 2011 12:42|
Cohen, G.B., V.S. Rangan, B.K. Chen, S. Smith, and D. Baltimore. 2000. The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation. J. Biol. Chem. 275: 23097–23105.
Corpas, F.J., J.B. Barroso, and L.A. del Rio. 2001. Peroxisomes as a source of reactive oxygen species and nitric oxide signal molecules in plant cells. Trends Plant Sci. 6: 145–150.
Desikan, R., S. A.-H.-Mackerness, J.T. Hancock, and S.J. Neill. 2001. Regulation of the Arabidopsis transcriptome by oxidative stress. Plant Physiol. 127: 159–172.
Desjardins, M. 2003. ER-mediated phagocytosis: a new membrane for new functions. Nat. Rev. Immunol. 3: 280–291.CrossRefMedline↵ Desvergne, B., and W. Wahli. 1999. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20: 649–688.
Di-Poi, N., N.S. Tan, L. Michalik, W. Wahli, and B. Desvergne. 2002. Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol. Cell. 10: 721–733.
Footitt, S., S.P. Slocombe, V. Larner, S. Kurup, Y. Wu, T. Larson, I. Graham, A. Baker, and M. Holdsworth. 2002. Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP. EMBO J. 21: 2912–2922.
Gaedeke, N., M. Klein, U. Kolukisaoglu, C. Forestier, A. Müller, M. Ansorge, D. Becker, Y. Mamnun, K. Kuchler, B. Schulz, et al. 2001. The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement. EMBO J. 20: 1875–1887.
Gavva, N.R., S.C. Wen, P. Daftari, M. Moniwa, Y.M. Yang, L.P. Yang-Feng, E. Seto, J.R. Davie, and C.K. Shen. 2002. NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor. Genomics. 79: 423–431.
Geuze, H.J., J.L. Murk, A.K. Stroobants, J.M. Griffith, M.J. Kleijmeer, A.J. Koster, A.J. Verkleij, B. Distel, and H.F. Tabak. 2003. Involvement of the endoplasmic reticulum in peroxisome formation. Mol. Biol. Cell. 14: 2900–2907.
González-Gaitán, M. 2003. Signal dispersal and transduction through the endocytic pathway. Nat. Rev. Mol. Cell Biol. 4: 213–224.
Gould, S.G., D. Valle, and G.V. Raymond. 2001. The peroxisome biogenesis disorders. The Metabolic and Molecular Bases of Inherited Disease. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, editors. McGraw-Hill, New York. 3181–3217.
Hancock, J.F. 2003. Ras proteins: different signals from different locations. Nat. Rev. Mol. Cell Biol. 4: 373–385.
Hettema, E.H., and H.F. Tabak. 2000. Transport of fatty acids and metabolites across the peroxisomal membrane. Biochim. Biophys. Acta. 1486: 18–27.
Hu, J., M. Aguirre, C. Peto, J. Alonso, J. Ecker, and J. Chory. 2002. A role for peroxisomes in photomorphogenesis and development of Arabidopsis. Science. 297: 405–409.
Jedd, G., and N.-H. Chua. 2000. A new self-assembled peroxisomal vesicle required for efficient resealing of the plasma membrane. Nat. Cell Biol. 2: 226–231.
Kersten, S., B. Desvergne, and W. Wahli. 2000. Roles of PPARs in health and disease. Nature. 405: 421–424.
Kimura, A., Y. Takano, I. Furusawa, and T. Okuno. 2001. Peroxisomal metabolic function is required for appressorium-mediated plant infection by Colletotrichum lagenarium. Plant Cell. 13: 1945–1957.
Lin, Y., L. Sun, L.V. Nguyen, R.A. Rachubinski, and H.M. Goodman. 1999. The Pex16p homolog SSE1 and storage organelle formation in Arabidopsis seeds. Science. 284: 328–330.
Lopez-Huertas, E., W.L. Charlton, B. Johnson, I.A. Graham, and A. Baker. 2000. Stress induces peroxisome biogenesis genes. EMBO J. 19: 6770–6777.
Ma, L., Y. Gao, L. Qu, Z. Chen, J. Li, H. Zhao, and X.W. Deng. 2002. Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis. Plant Cell. 14: 2383–2398.
Matsumoto, N., S. Tamura, and Y. Fujiki. 2003. The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. Nat. Cell Biol. 5: 454–460.
Michalik, L., B. Desvergne, C. Dreyer, M. Gavillet, R.N. Laurini, and W. Wahli. 2002. PPAR expression and function during vertebrate development. Int. J. Dev. Biol. 46: 105–114.
Mohan, K.V., I. Som, and C.D. Atreya. 2002. Identification of a type 1 peroxisomal targeting signal in a viral protein and demonstration of its targeting to the organelle. J. Virol. 76: 2543–2547.
Motley, A.M., E.H. Hettema, R. Ketting, R. Plasterk, and H.F. Tabak. 2000. Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes. EMBO Rep. 1: 40–46.
Newmeyer, D.D., and S. Ferguson-Miller. 2003. Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 112: 481–490.
Petriv, O.I., D.B. Pilgrim, R.A. Rachubinski, and V.I. Titorenko. 2002. RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders. Physiol. Genomics. 10: 79–91.
Powers, J.M., and H.W. Moser. 1998. Peroxisomal disorders: genotype, phenotype, major neuropathologic lesions, and pathogenesis. Brain Pathol. 8: 101–120.
Sarmiento, C., J.H.E. Ross, E. Herman, and D.J. Murphy. 1997. Expression and subcellular targeting of a soybean oleosin in transgenic rapeseed. Implications for the mechanism of oil-body formation in seeds. Plant J. 11: 783–796.
Scorrano, L., S.A. Oakes, J.T. Opferman, E.H. Cheng, M.D. Sorcinelli, T. Pozzan, and S.J. Korsmeyer. 2003. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science. 300: 135–139.
Sorkin, A., and M. von Zastrow. 2002. Signal transduction and endocytosis: close encounters of many kinds. Nat. Rev. Mol. Cell Biol. 3: 600–614.
Tan, N.S., N.S. Shaw, N. Vinckenbosch, P. Liu, R. Yasmin, B. Desvergne, W. Wahli, and N. Noy. 2002. Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol. Cell. Biol. 22: 5114–5127.
Thines, E., R.W.S. Weber, and N.J. Talbot. 2000. MAP kinase and protein kinase A-dependent mobilization of triacylglycerols and glycogen during appressorium turgor generation by Magnaporthe grisea. Plant Cell. 12: 1703–1718.
Titorenko, V.I., and R.A. Rachubinski. 1998. Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis. Mol. Cell. Biol. 18: 2789–2803.
Titorenko, V.I., and R.A. Rachubinski. 2001. The life cycle of the peroxisome. Nat. Rev. Mol. Cell Biol. 2: 357–368.
Titorenko, V.I., D.M. Ogrydziak, and R.A. Rachubinski. 1997. Four distinct secretory pathways serve protein secretion, cell surface growth, and peroxisome biogenesis in the yeast Yarrowia lipolytica. Mol. Cell. Biol. 17: 5210–5226.
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