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Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats

Title:

Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats

Caruana, Douglas A. and Reed, Sean J. and Sliz, Diane J. and Chapman, C. Andrew (2007) Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats. Neuroscience Letters, 426 (1). pp. 6-11. ISSN 0304-3940

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Official URL: http://dx.doi.org/10.1016/j.neulet.2007.08.025

Abstract

Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated whether dopamine may modulate the induction of long-term potentiation (LTP) and depression (LTD) in piriform cortex inputs to layer II of the lateral entorhinal cortex in awake rats. Groups of animals were pretreated with either saline or the selective dopamine reuptake inhibitor GBR12909 prior to low or high frequency stimulation to induce LTD or LTP. In saline-treated groups, synaptic responses were potentiated to 122.4 ±6.4% of baseline levels following LTP induction, and were reduced to 84.5 ±4.9% following induction of LTD. Changes in synaptic responses were maintained for up to 60 minutes and returned to baseline levels within 24 hours. In contrast, induction of both LTP and LTD was blocked in rats pretreated with GBR12909. Dopaminergic suppression of synaptic plasticity in the entorhinal cortex may serve to restrain activity-dependent plasticity during reward-relevant behavioral states or during processing of novel stimuli.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Caruana, Douglas A. and Reed, Sean J. and Sliz, Diane J. and Chapman, C. Andrew
Journal or Publication:Neuroscience Letters
Date:2007
Funders:
  • Natural Sciences and Engineering Research Council of Canada
Keywords:memory, olfaction, piriform, parahippocampal, ventral tegmental area, rat
ID Code:6409
Deposited By:Spectrum User
Deposited On:26 Oct 2009 14:42
Last Modified:08 Dec 2010 18:54
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