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Behavioral and hormonal regulation of expression of the clock protein, PER2, in the bed nucleus of the stria terminalis

Title:

Behavioral and hormonal regulation of expression of the clock protein, PER2, in the bed nucleus of the stria terminalis

Amir, Shimon and Stewart, Jane (2009) Behavioral and hormonal regulation of expression of the clock protein, PER2, in the bed nucleus of the stria terminalis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33 (8). pp. 1321-1328. ISSN 0278-5846

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Official URL: http://dx.doi.org/doi:10.1016/j.pnpbp.2009.04.003

Abstract

PER2, a key molecular component of the mammalian circadian clock, is expressed rhythmically in many brain areas and peripheral tissues in mammals. Here we review findings from our work on the nature and regulation of rhythms of expression of PER2 in two anatomically and neurochemically defined subregions of the central extended amygdala, the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEA). Daily rhythms in the expression of PER2 in these regions are coupled to those of the master circadian pacemaker, the suprachiasmatic nucleus (SCN) but, importantly, they are sensitive to homeostatic perturbations and to hormonal states that directly influence motivated behavior.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Amir, Shimon and Stewart, Jane
Journal or Publication:Progress in Neuro-Psychopharmacology and Biological Psychiatry
Date:November 2009
Funders:
  • CIHR, FRSQ, NSERC, CURC
ID Code:6594
Deposited By:SHIMON AMIR
Deposited On:26 Apr 2010 15:56
Last Modified:08 Dec 2010 18:33
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