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Airborne Pollutants and Lung Surfactant: Biophysical Impacts of Surface Oxidation Reactions

Title:

Airborne Pollutants and Lung Surfactant: Biophysical Impacts of Surface Oxidation Reactions

Selladurai, Sahana L. (2015) Airborne Pollutants and Lung Surfactant: Biophysical Impacts of Surface Oxidation Reactions. Masters thesis, Concordia University.

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Abstract

Lung surfactant comprises a lipid-protein film that coats the alveolar surface and serves to prevent alveolar collapse upon repeated breathing cycles. Exposure of lung surfactant to high concentrations of airborne pollutants, for example tropospheric ozone, can chemically modify the lipid and protein components. These chemical changes can impact the film functionality by decreasing the film's collapse pressure (minimum surface tension attainable), altering its mechanical and flow (rheology) properties and modifying lipid reservoir formation essential for re-spreading of the film during the inhalation process. In this research, we use Langmuir monolayers spread at the air-water interface as model membranes where the compression and expansion of the film mimics the breathing cycle. The impact of ozone exposure on model lung surfactant films is measured using a Langmuir film balance, Brewster angle microscopy and a pendant drop tensiometer as a function of film and subphase composition. Oxidation is shown to lower squeeze-out pressure, sometimes alter line tension (and film morphology) and in some cases visibly reduce the viscoelastic properties of the film when compared to controls. These reductions in functionality of the films are highly dependent on film and subphase composition, where for example, the use of a physiologically relevant buffer makes these films more fluid and sometimes more susceptible to oxidation. These findings can lead to a better understanding on the impact of continuous exposure to high levels of ozone on the mechanical process of breathing, as well as understanding the roles of certain lung surfactant components in this process.

Divisions:Concordia University > Faculty of Arts and Science > Chemistry and Biochemistry
Item Type:Thesis (Masters)
Authors:Selladurai, Sahana L.
Institution:Concordia University
Degree Name:M. Sc.
Program:Chemistry
Date:17 September 2015
Thesis Supervisor(s):DeWolf, Christine
ID Code:980553
Deposited By: SAHANA-LOGANATH SELLADURAI
Deposited On:03 Nov 2015 17:25
Last Modified:18 Jan 2018 17:51
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