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Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles

Title:

Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles

Varady, Krista A., Dam, Vi T., Klempel, Monica C., Horne, Matthew, Cruz, Rani, Kroeger, Cynthia M. and Santosa, Sylvia (2015) Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles. Scientific Reports, 5 . p. 7561. ISSN 2045-2322

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Official URL: http://dx.doi.org/10.1038/srep07561

Abstract

Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid (FFA) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma FFA profiles in the context of weight loss, and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women (BMI 30–39.9 kg/m2) 25–65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Body weight, BMI, fat mass, total cholesterol, LDL-C and triglyceride concentrations decreased (P < 0.05) in both groups. Total FFA concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, FFA concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms.

Divisions:Concordia University > Faculty of Arts and Science > Exercise Science
Item Type:Article
Refereed:Yes
Authors:Varady, Krista A. and Dam, Vi T. and Klempel, Monica C. and Horne, Matthew and Cruz, Rani and Kroeger, Cynthia M. and Santosa, Sylvia
Journal or Publication:Scientific Reports
Date:2015
Funders:
  • Concordia Open Access Author Fund
Digital Object Identifier (DOI):10.1038/srep07561
ID Code:982230
Deposited By: DANIELLE DENNIE
Deposited On:17 Mar 2017 19:16
Last Modified:18 Jan 2018 17:54
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