Login | Register

17β-estradiol locally increases phasic dopamine release in the dorsal striatum

Title:

17β-estradiol locally increases phasic dopamine release in the dorsal striatum

Shams, Waqqas M., Cossette, Marie-Pierre, Shizgal, Peter ORCID: https://orcid.org/0000-0003-4265-0792 and Brake, Wayne G. (2017) 17β-estradiol locally increases phasic dopamine release in the dorsal striatum. Neuroscience Letters . ISSN 0304-3940 (In Press)

[img]
Preview
Text (application/pdf)
brake-neuroscience-letters-2017.pdf - Accepted Version
Available under License Spectrum Terms of Access.
2MB

Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anaesthetized (1.5 mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of ∼ 20–25 pg/ml. DA release was evoked every 1 min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8 pg/μl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.

Divisions:Concordia University > Faculty of Arts and Science > Psychology
Item Type:Article
Refereed:Yes
Authors:Shams, Waqqas M. and Cossette, Marie-Pierre and Shizgal, Peter and Brake, Wayne G.
Journal or Publication:Neuroscience Letters
Date:22 November 2017
Funders:
  • Natural Sciences and Engineering Research Council (NSERC) of Canada [WGB: RGPIN-2016-06653; PS, RGPIN-308-11]
Digital Object Identifier (DOI):10.1016/j.neulet.2017.11.039
Keywords:Estrogens; fast-scan cyclic voltammetry
ID Code:983224
Deposited By: DANIELLE DENNIE
Deposited On:22 Nov 2017 19:38
Last Modified:20 Nov 2018 01:00

References:

M.J. Bannon, E.E. Bannon, K.T. Bannon Dopamine eLS John Wiley & Sons, Ltd, Chichester (2012) https://doi.org/10.1002/9780470015902.a0000279.pub3

J.B. Becker, J.H. Cha Estrous cycle-dependent variation in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis Behav. Brain. Res., 35 (1989), pp. 117–125

J.B. Becker Direct effect of 17β-estradiol on striatum: sex differences in dopamine release Synap., 5 (1990), pp. 157–164

J.B. Becker Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis Neurosci. Lett., 118 (1990), pp. 169–171

S.A. Castner, L. Xiao, J.B. Becker Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies Brain Res., 610 (1993), pp. 127–134

T.J. Bazzett, J.B. Becker Sex differences in the rapid and acute effects of estrogen on striatal D2 dopamine receptor binding Brain Res., 637 (1994), pp. 163–172

L. Xiao, J.B. Becker Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy Neurosci. Lett., 180 (1994), pp. 155–158

J.B. Becker, C.N. Rudick Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: a microdialysis study Pharmacol. Biochem. Behav., 64 (1999), pp. 53–57

G.E. Gillies, S. McArthur Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines Pharmacol. Rev., 62 (2010), pp. 155–198

J.B. Becker, M.E. Beer The influence of estrogen on nigrostriatal dopamine activity: behavioral and neurochemical evidence for both pre- and postsynaptic components Behav. Brain Res., 19 (1986), pp. 27–33

W.M. Shams, C. Sanio, M. Quinlan, W.G. Brake 17β-estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo Neurosci ., 330 (2016), pp. 162–170

W. Schultz Multiple reward signals in the brain Nat. Rev Neurosci., 1 (2000), pp. 199–207

A.A. Grace Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia Neurosci., 41 (1991), pp. 1–24

T.L. Thompson, R.L. Moss Estrogen regulation of dopamine release in the nucleus accumbens: genomic- and nongenomic-mediated effects J. Neurochem., 62 (1994), pp. 1750–1756

B. Liu, J. Xie Increased dopamine release in vivo by estradiol benzoate from the central amygdaloid nucleus of Parkinson’s disease model rats J. Neurochem., 90 (2004), pp. 654–658

A. Almey, N.M. Hafez, A. Hantson, W.G. Brake Deficits in latent inhibition induced by estradiol replacement are ameliorated by haloperidol treatment Front. Behav. Neurosci., 7 (2013), pp. 1–8

G. Paxinos, C. Watson The rat brain in stereotaxic coordinates (sixth ed.)Elsevier Inc., Amsterdam (2007)

M.-P. Cossette, K. Conover, P. Shizgal The neural substrates for the rewarding and dopamine-releasing effects of medial forebrain bundle stimulation have partially discrepant frequency responses Behav. Brain Res., 297 (2006), pp. 345–358

A. Almey, E. Cannell, K. Bertram, E. Filardo, T.A. Milner, W.G. Brake Medial prefrontal cortical estradiol rapidly alters memory system bias in female rats: ultrastructural analysis reveals membrane-associated estrogen receptors as potential mediators Endocrinol., 155 (2014), pp. 4422–4432

M.L.A.V. Heien, P.E.M. Phillips, G.D. Stuber, A.T. Seipel, M. Wightman Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity Anal., 128 (2003), pp. 1413–1419

B. Efron, R.J. Tibshirani An introduction to the bootstrap Chapman & Hall/CRC (1993)

A. Almey, E.J. Filardo, T.A. Milner, W.G. Brake Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization Endocrinol., 153 (2012), pp. 5373–5383

A. Almey, T.A. Milner, W.G. Brake Estrogen receptor α and G-protein coupled estrogen receptor 1 are localized to GABAergic neurons in the dorsal striatum Neurosci. Lett., 622 (2016), pp. 118–123

K.N. Schultz, S.A. von Esenwein, M. Hu, A.L. Bennett, R.T. Kennedy, S. Musatov, C.D. Toran-Allerand, M.G. Kaplitt, L.J. Young, J.B. Becker Viral vector-mediated overexpression of estrogen receptor-(in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release J. Neurosci., 29 (2009), pp. 1897–1903

M. Hu, C.J. Watson, R.T. Kennedy, J.B. Becker Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum Synap., 59 (2006), pp. 122–124
All items in Spectrum are protected by copyright, with all rights reserved. The use of items is governed by Spectrum's terms of access.

Repository Staff Only: item control page

Downloads per month over past year

Research related to the current document (at the CORE website)
- Research related to the current document (at the CORE website)
Back to top Back to top