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Neighbourhood disadvantage and behavioural problems during childhood and the risk of cardiovascular disease risk factors and events from a prospective cohort


Neighbourhood disadvantage and behavioural problems during childhood and the risk of cardiovascular disease risk factors and events from a prospective cohort

Kakinami, Lisa, Serbin, Lisa A., Stack, Dale M., Karmaker, Shamal Chandra, Ledingham, Jane E. and Schwartzman, Alex E. (2017) Neighbourhood disadvantage and behavioural problems during childhood and the risk of cardiovascular disease risk factors and events from a prospective cohort. Preventive Medicine Reports, 8 . pp. 294-300. ISSN 22113355

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Official URL: http://dx.doi.org/10.1016/j.pmedr.2017.10.003


Both low socioeconomic status (SES) and behavioural problems in childhood are associated with cardiovascular disease (CVD) in adulthood, but their combined effects on CVD are unknown. Study objectives were to investigate the effect of neighbourhood level SES and behavioural problems during childhood on the development of CVD risk factors and events during adulthood. Participants were from a longitudinal cohort (n = 3792, baseline: 6–13 years of age) of Montreal children, followed from 1976 to 2010. SES was a composite measure of neighbourhood income, employment, education, and single-parent households separately assessed from census micro data sets in 1976, 2001, and 2006. Behavioural problems were assessed based on sex-specific peer assessments. CVD events were from medical records. Sex-stratified multivariable Cox regression models adjusted for age, frequency of medical visits, and parental history of CVD. Males from disadvantaged neighbourhoods during childhood were 2.06 (95% CI: 1.09–3.90, p = 0.03) and 2.51 (95% CI: 1.49–4.22, p = 0.0005) times more likely to develop a CVD risk factor or an event, respectively, than males not from disadvantaged neighbourhoods. Aggressive males were also 50% more likely to develop a CVD risk factor or event. Females from disadvantaged neighbourhoods during childhood were 1.85 (95% CI: 1.33–2.59, p = 0.0003) times more likely to develop a CVD risk factor. Future studies should aim to disentangle the interpersonal from the socioeconomic effects on CVD incidence.

Divisions:Concordia University > Faculty of Arts and Science > Mathematics and Statistics
Item Type:Article
Authors:Kakinami, Lisa and Serbin, Lisa A. and Stack, Dale M. and Karmaker, Shamal Chandra and Ledingham, Jane E. and Schwartzman, Alex E.
Journal or Publication:Preventive Medicine Reports
Date:December 2017
  • Concordia Open Access Author Fund
  • Social Sciences and Humanities Research Council of Canada
  • Canadian Institutes for Health Research
  • Fonds de recherche sur la société et la culture
Digital Object Identifier (DOI):10.1016/j.pmedr.2017.10.003
Keywords:Neighbourhood disadvantage; Cardiovascular risk; Prospective cohort; Socioeconomic status; Longitudinal
ID Code:983558
Deposited On:13 Mar 2018 18:27
Last Modified:13 Mar 2018 18:27


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